Results 131 to 140 of about 1,767,596 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Association of Depressive Symptomology and Psychological Trauma with Diabetes Control Among Older American Indian Women: Does Social Support Matter?

, 2017
Aims—Among older American Indian women with type 2 diabetes (T2DM), we examined the association between mental health and T2DM control and if social support modifies the association.
Winchester, Blythe, Goins, R. Turner, Bradley, Vickie L., Gonzales, Kelly, Noonan, Carolyn   +4 more
core   +1 more source

A cross-sectional study on achievement of performances of Kayakalp program parameters between a Medical College and District Hospital of West Bengal

MRIMS Journal of Health Sciences
Background “Kayakalp” is a National initiative to give awards to those public health facilities that demonstrate high level of cleanliness, hygiene, and infection control. It encourages every public health facility in the country to work toward standards
Tanusri Ray, Eashin Gazi, Tushar Kanti Saha, Kaushik Ishore   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Self-paced heart rate control during treadmill exercise for persons with gait impairment: a case study

Frontiers in Control Engineering
Introduction:A self-paced (SP) heart rate (HR) control system proposed in a previous study was found to be feasible for healthy participants. The aims of this work were to investigate whether the SP HR control system is feasible to achieve accurate HR ...
Hanjie Wang, Diana Guimaraes, Tobias Nef, Kenneth J. Hunt   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The relationship between work and non-work support and work-life balance in Taiwan

, 2009
The aim of this study is to explore the relationship between employees' supportive resource (workplace support and non-work support) and their work-life balance in Taiwan.
Chang, Ruby Yi-Ju
core  

Adolescents Spending Time with Their Parents: Does It Matter?

Youth
The current study aims to explore the relevance of ‘time spent with parents’ for different risk behaviors (i.e., alcohol use, smoking, gambling and problematic social media use), peer factors (i.e., time spent with peers, peer pressure and peer support ...
Ina Koning, Carmen Voogt
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Single phase inverter system using proportional resonant current control

, 2017
This paper presents the harmonic reduction performance of proportional resonant (PR) current controller in single phase inverter system connected to nonlinear load.
Chen, K.C., K.C. Chen, Aziz, R., Salimin, Suriana, Aziz, Rebaz, Zulkifli, S. A., Salimin, S., S. Salimin, R. Aziz, S. A. Zulkifli   +9 more
core   +1 more source