Results 131 to 140 of about 4,809,971 (303)

Cancer‐Directed Therapy in the Last Month of Life and Its Association With ICU Utilisation in a Tertiary Care Centre in India

Cancer Medicine
Background Use of cancer‐directed therapies (CDT) near the end of life is an established indicator of quality in oncology care. However, evidence from low‐ and middle‐income countries (LMICs), including India, remains limited.
Kunal Das, Arun Ghoshal, Anuja Damani, Krithika S. Rao, Seema Rajesh Rao, Shreya Nair, S. Gayatri, Arnavi Udapure, Naveen Salins   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Vaccination against HPV: Easier said than done?

Human Vaccines & Immunotherapeutics, 2023
Henri-Corto Stoeklé, Sakina Sekkate, Jean-Marc Ayoubi, Jaafar Bennouna, Philippe Beuzeboc, Christian Hervé   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A supportive care intervention for people with metastatic melanoma being treated with immunotherapy : a pilot study assessing feasibility, perceived benefit, and acceptability

, 2019
Introduction: Increasing numbers of metastatic melanoma (MM) patients are receiving immunotherapy treatment, including pembrolizumab, and the impact on their well-being is underexplored.
McNeil, Catriona, Marthick, Michael, Lomax, Anna J., Levy, David, Dhillon, Haryana M., Kao, Steven, Nielsen, Theresa, Lacey, Judith (R19507)   +7 more
core   +1 more source

Decision-making and autonomy among participants in early-phase cancer immunotherapy trials: a qualitative study

BMC Cancer
Background Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent.
Jonathan Avery, Jennifer A.H. Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim, Lynda G. Balneaves   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Facilitating patient-oncologist communication in advanced treatment-resistant cancer: development and feasibility testing of a question prompt list

Pilot and Feasibility Studies
Background Patients’ expectations regarding medical information in advanced stages of cancer are still poorly understood. Tailoring information to advanced cancer patients is a subtle task.
A. Rault, S. Dolbeault, J. Terrasson, C. Bouleuc, P. Cottu, S. Piperno-Neumann, M. Rodrigues, P. Vaflard, A. Brédart   +8 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source