Results 101 to 110 of about 2,659,694 (301)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Klinik Psikoloji DergisiDue to the limited number of studies in the literature conducted to examine the relationship be-tween emotion regulation strategies and the obsessive-compulsive disorder symptoms, the current study aimed at examining the role of emotion regulation ...
Tuğba Çapar Taşkesen, Mujgan Inozu
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
De la persistance de la dot dans certains pays africains nonobstant sa suppression de leurs législations [PDF]
Mouvements et Enjeux SociauxAprès un examen attentif des codes des personnes et de la famille de certains pays africains, il en ressort que les législateurs de ces Etats adoptent, pour contrer sa dénaturation, deux positions opposées.
Patrice POMBO KAPIKANYA
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Hostility, Harassment, and Violence: On the Limits of ‘Free Speech’ for Minority Feminist Scholars
Atlantis, 2020 Following the rich tradition of Indigenous and Black feminists and authors, this article makes use of storytelling to explore the limits of freedom of speech in the academy for feminist scholars belonging to socially marginalized groups and ...
Robyn Bourgeois
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Spormetre Beden Eğitimi ve Spor Bilimleri DergisiBu araştırma ile basketbolcularda duygu düzenleme ve bilinçli farkındalık (mindfulness) düzeylerinin farklı değişkenler açısından incelenmesi amaçlanmaktadır. Kolayda örnekleme yöntemi kullanılarak belirlenen, Google formlar aracılığıyla çevrimiçi olarak
Mehmet Ali Üzgü, Oğuzhan Acıbunar
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source