Results 181 to 190 of about 2,659,694 (301)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Trends, magnitude and determinants of viral load suppression among HIV patients on highly active anti-retroviral therapy in Tigray region, Ethiopia: a retrospective study (2016-2024). [PDF]
BMC Infect DisKidane KM +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Is It Time to Retire Aldosterone Suppression Testing? [PDF]
Am J HypertensKline GA +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Viral load suppression and associated factors among patients receiving ART in Mekelle, Ethiopia: a cross-sectional study. [PDF]
BMC Infect DisGebreyohannes H +3 more
europepmc +1 more source
Emerging strategies to target metastasis and therapy resistance in melanoma
Molecular Oncology, EarlyView.Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley +1 more source
Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics. [PDF]
Proc Natl Acad Sci U S AGarderes PM, Feldman DE, Bouchard KE.
europepmc +1 more source
Suppressing the Suppression Effect
The suppression effect, first identified by Byrne (1989), refers to a systematic failure to conform to the monotonicity principle of classical truth-functional propositional logic. When additional premises are introduced that conflict with initial assumptions, individuals often withdraw otherwise valid inferences, opting instead for uncertain ...
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source