Results 311 to 320 of about 880,593 (358)
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Immunology Today, 1983
B cells can influence an immune response in an antigen-specific manner by generating antibody which shuts down the response through negativefeedback. But there is growing evidence that B cells can also act upon antibody production as non-specific suppressor cells.
K M, Gilbert, M K, Hoffmann
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B cells can influence an immune response in an antigen-specific manner by generating antibody which shuts down the response through negativefeedback. But there is growing evidence that B cells can also act upon antibody production as non-specific suppressor cells.
K M, Gilbert, M K, Hoffmann
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The Biomedical & Life Sciences Collection, 2016
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
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A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
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Long‐term suppressor cell lines. II. Suppressor‐target interactions
European Journal of Immunology, 1984AbstractLong‐term nonhybridized murine suppressor T cell (Ts) lines, some of which have been in culture for over one year, are genetically restricted in their ability to suppress proliferation of primed lymph node cells (LNC). The genetic restriction maps to the I region of the major histocompatibility complex and resides in either the I‐A, I‐E or I‐J ...
J D, Levich, W O, Weigle, D E, Parks
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BioEssays, 1990
AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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Yeast UAA suppressors effective in ψ+ strains serine-inserting suppressors
Journal of Molecular Biology, 1979Over 200 revertants that suppressed three or more UAA markers were isolated in a haploid strain of yeast, Saccharomyces cerevisiae, containing the ψ+ cytoplasmic determinant which increases the efficiency of action of certain suppressors. These revertants were grouped into classes on the basis of suppression of four nutritional markers and the ...
B I, Ono, J W, Stewart, F, Sherman
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Blood, 2009
In this issue of Blood , Brockman and colleagues demonstrate that active HIV replication rapidly triggers production of the immunosuppressive cytokine IL-10 and that IL-10 reversibly inhibits HIV-directed T-cell activity.[1][1] Application of these findings may ultimately lead to therapies ...
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In this issue of Blood , Brockman and colleagues demonstrate that active HIV replication rapidly triggers production of the immunosuppressive cytokine IL-10 and that IL-10 reversibly inhibits HIV-directed T-cell activity.[1][1] Application of these findings may ultimately lead to therapies ...
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Current Opinion in Genetics & Development, 2000
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
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Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
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Annual Review of Biochemistry, 1993
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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Annual Review of Genetics, 1990
INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
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INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
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