Results 151 to 160 of about 1,011,947 (286)

Correlations Between Osteocyte Lacuno‐Canalicular Network and Material Characteristics in Healthy and Mechanically Stimulated Murine Tibiae

Advanced NanoBiomed Research, EarlyView.
This article reveals how calcium content, mineral nanostructure, and lacuno‐canalicular network (LCN) organization interact to shape bone heterogeneity in mouse tibiae. Advanced multimodal imaging uncovers that mechanical loading promotes mature mineral structures even in low‐calcium regions, highlighting LCN‐driven mineralization and offering new ...
Victoria Schemenz, Maximilian Rummler, Alexander van Tol, Isabela Vitienes, Tobias Thiele, Markus A. Hartmann, Manfred Burghammer, Peter Fratzl, Richard Weinkamer, Bettina M. Willie, Wolfgang Wagermaier   +10 more
wiley   +1 more source

Alkoxysulfonium Salts Unlock Access to New Aryl Sulfonium Salts for Cross‐Coupling

Angewandte Chemie, EarlyView.
Hard‐to‐access (hetero)aryl sulfonium salts are prepared using stable methoxysulfonium salts in combination with the magnesiation of (hetero)aryl bromides. The approach allows access to aryl sulfonium salts bearing electron‐deficient (hetero)aryl rings, or electron‐rich aryl motifs in which the sulfonium motif resides at an alternative position on the ...
Rachel E. Brown, Navpreet Kaur, Anne‐Chloe M. A. Nassoy, Ciro Romano, David J. Procter   +4 more
wiley   +2 more sources

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox‐Mediated Radical Cross‐Coupling

Angewandte Chemie, EarlyView.
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +2 more sources

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, EarlyView.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

Iron Catalyzed Aryl–Aryl Kumada Cross‐Coupling: A Mechanistic and Computational Investigation

Angewandte Chemie, EarlyView.
Despite intense interest, the mechanism of iron‐catalyzed aryl–aryl cross‐coupling remains poorly understood. Combining Mössbauer spectroscopy, kinetics analysis, and DFT computations these studies reveal a novel Fe(I)/Fe(II)/Fe(III) catalytic for aryl–aryl cross‐coupling mediated by an Fe(II) PCNHCP Pincer complex. These findings close a key knowledge
Jatin Panda, Magali Gimeno, Amrita Gogoi, Zeqing Chen, Subhash Garhwal, Laura Levy, Alexander Kaushansky, Natalia Fridman, Jos Briggs‐Pritchard, Renana Gershoni‐Poranne, Michael L. Neidig, Graham de Ruiter   +11 more
wiley   +2 more sources

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, EarlyView.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +2 more sources

Quantitation of Select Terpenes/Terpenoids and Nicotine Using Gas Chromatography–Mass Spectrometry with High-Temperature Headspace Sampling

ACS Omega, 2020
Trinh-Don Nguyen, Seamus Riordan-Short, Thu-Thuy T. Dang, Rob O’Brien, Matthew Noestheden   +4 more
doaj   +1 more source

Mid-term Outcomes Following Primary Covered Stent Implantation in Supra-Aortic Arch Vessels for Atherosclerotic Occlusive Disease. [PDF]

Vasc Specialist Int
Sachsamanis G, Kasprzak PM, Schierling W, Pavlovic M, Zygouridou E, Pfister K.   +5 more
europepmc   +1 more source

Computational Predictive Modeling of Surgical Outcomes in Total Anomalous Pulmonary Venous Connection: Assessing the Impact of Pulmonary Venous Confluence Size on Preoperative Planning. [PDF]

J Cardiovasc Transl Res
Jin J, Shi Z, Gao Q, Yu J, Jin I, Liang J, Fan X.   +6 more
europepmc   +1 more source