Results 121 to 130 of about 36,949 (217)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang   +19 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

open access: yesAdvanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang   +11 more
wiley   +1 more source

Covalent Network Formation Rate Controls Depletion-Induced Supramolecular Assembly in Hybrid Double Network Hydrogels. [PDF]

open access: yesAngew Chem Int Ed Engl
Özel M   +7 more
europepmc   +1 more source

Self‐Healing Pd(II) Cage Metallogels for Iodine Capture in Water and Heterogeneous Photocatalysis

open access: yesAdvanced Science, EarlyView.
Two carbazole‐derived metal‐organic cages hierarchically self‐assemble into supramolecular metallogels that integrate autonomous self‐healing, reversible stimuli responsiveness, high‐capacity aqueous iodine capture, and visible‐light‐driven photocatalytic sulfide oxidation within a single multifunctional platform.
Monotosh Dalapati   +3 more
wiley   +1 more source

Controlling Supramolecular Assembly through Peptide Chirality. [PDF]

open access: yesACS Appl Mater Interfaces
Chatterjee M   +7 more
europepmc   +1 more source

Sea Cucumber‐Inspired Double‐Network Biopolymer Hydrogels for Programmable Soft Machines

open access: yesAdvanced Science, EarlyView.
Inspired by the mutable dermis of sea cucumbers, the collagen‐alginate double‐network elastomeric (CoDE) hydrogel achieves programmable, recoverable, and functional mechanical behavior. The CoDE hydrogel mimics the mutable stiffness of the sea cucumber dermis through a densified collagen cryogel scaffold that is secondarily reinforced by a dissipative,
Luo Yan   +3 more
wiley   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

open access: yesAdvanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi   +8 more
wiley   +1 more source

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