Synthesis and Reactivity of New 1-Pentafluorophenyl-1Hpyrrole Derivatives
Molecules, 2003 We present 1-pentafluorophenyl-1H-pyrrole and some of its electrophilic substitution reactions: formylation and acetylations. The 2-substituted products formed in these reactions are selectively and in high yield converted into 3-substituted products by ...
Daniel Végh +1 more
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Supramolecular synthons and crystal structure prediction of organic compounds [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2004 The strategy taking into account regularities of crystal structure formation and results of theoretical crystal structure prediction has been proposed as a tool for crystal engineering. The role of the symmetry of the supramolecular associates (synthons) in the symmetry of the crystal structure is suggested.
Detlef W. M. Hofmann +2 more
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Supramolecular Synthon Promiscuity in Phosphoric Acid–Dihydrogen Phosphate Ionic Cocrystals
Crystal Growth & Design, 2022 Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ionizable APIs and, more recently, pharmaceutical cocrystals can address low solubility and other relevant ...
Molly M. Haskins +2 more
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Crystal Engineering of Ionic Cocrystals Sustained by Azolium···Azole Heterosynthons
Pharmaceutics, 2022 Crystal engineering of multi-component molecular crystals, cocrystals, is a subject of growing interest, thanks in part to the potential utility of pharmaceutical cocrystals as drug substances with improved properties. Whereas molecular cocrystals (MCCs)
Maryam Rahmani +3 more
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New Titanium Imido Synthons: Syntheses and Supramolecular Structures
Inorganic Chemistry, 2005 Reactions of Ti(NMe(2))(2)Cl(2) with a wide range of primary alkyl and arylamines RNH(2) afforded the corresponding 5-coordinate imido titanium compounds Ti(NR)Cl(2)(NHMe(2))(2) (R = (t)Bu (1), (i)Pr (2), CH(2)Ph (3), Ph (4), 2,6-C(6)H(3)Me(2) (5), 2,6-C(6)H(3)(i)Pr(2) (6), 2,4,6-C(6)H(2)F(3) (7), 2,3,5,6-C(6)HF(4) (8), C(6)F(5) (9), 4-C(6)H(4)Cl (10),
Adams, Nico +8 more
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Self-assembly of cis- and trans-cyclic-1,2-diols. Supramolecular synthon equivalence between cis-1,2-diols and primary amides [PDF]
, 2005 Inspite of the fact that the self-assembly of compounds containing hydroxyl group has been enormously documented in the literature, our studies with aliphatic cyclic diols have offered the unique opportunity to examine the self-assembly of gauche and ...
Begum, N.S. +3 more
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Supramolecular assemblies of copper(II) complexes: supramolecular synthon transferability and magnetic properties [PDF]
Acta Crystallographica Section A Foundations and Advances, 2019 In the pursuit of new technologies there is exigency for novel materials with desired physical and chemical properties. Despite the fact that metal-based crystalline solids provide an access to properties that are typically unavailable or difficult to achieve in metal-free settings (i.e. magnetic or optical).
Borovina, Mladen +3 more
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Design of co-crystals/salts of some Nitrogenous bases and some derivatives of thiophene carboxylic acids through a combination of hydrogen and halogen bonds [PDF]
, 2014 BACKGROUND: The utility of N-heterocyclic bases to obtain molecular complexes with carboxylic acids is well studied. Depending on the solid state interaction between the N-heterocyclic base and a carboxylic acid a variety of neutral or ionic synthons are
Packianathan Muthiah, Samson Jennifer
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C–halogen…O supramolecular synthons:in situcryocrystallisation of 1,2-dihalotetrafluoroethane/HMPA adducts [PDF]
, 2013 The in situ cryocrystallisation technique has been used to obtain four adducts between hexamethylphosphortriamide and 1,2-dihalotetrafluoroethanes having iodine, bromine and chlorine as halogen-bonding donor atoms.
CAVALLO, GABRIELLA +5 more
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CrystalsMolecular reactions occur through functional groups that drive covalent synthesis. These reactions often proceed via catalytic processes, leading to the formation of time crystals, which can be integrated into shared molecules or reactions—a concept ...
Indrajit Chakraborty +4 more
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