Results 21 to 30 of about 1,102 (170)
Supramolecular synthons in hydrates and solvates of lamotrigine: a tool for cocrystal design. [PDF]
Acta Crystallogr B Struct Sci Cryst Eng MaterThe molecule of anti-epileptic drug lamotrigine [LAM; 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine] is capable of the formation of multicomponent solids. Such an enhanced tendency is related to the diverse functionalities of the LAM chemical groups able to form hydrogen bonds.
Pavlović G, Lekšić E, Meštrović E.
europepmc +4 more sources
1,1,2,2-Tetracyanocyclopropane (TCCP) as supramolecular synthon
Physical Chemistry Chemical Physics, 2016 The 1,1,2,2-tetracyanocyclopropane (TCCP) unit presents a synthetically accessible and versatile synthon that can interact with lone-pair or π-electrons by ‘non-covalent Carbon bonding’.
Antonio Bauzá +2 more
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Molecules, 2020 The success of innovative drugs depends on an interdisciplinary and holistic approach to their design and development. The supramolecular architecture of living systems is controlled by non-covalent interactions to a very large extent.
Joanna Bojarska +6 more
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Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals
IUCrJ, 2015 The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla +2 more
doaj +1 more source
From a Binary to a Quaternary Cocrystal: An Unusual Supramolecular Synthon [PDF]
Angewandte Chemie, 2019 AbstractFormation of a stoichiometric quaternary cocrystal consisting of resorcinol (RES), tetramethylpyrazine (TMP), phenazine (PHE) and pyrene (PYR) is described. A closed tetrameric resorcinol‐heterocycle synthon, unusual in that it has two different linker bases rather than just one, is observed in this four‐component solid.
Mithun Paul, Gautam R. Desiraju
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Rapidly Diversifying Hydrogen‐Bonded Organic Frameworks With Permanent Porosity
Angewandte Chemie, EarlyView.This article reviews diversifying hydrogen‐bonded organic frameworks (HOFs) with permanent porosity reported over the past 15 years, based on the molecular structures of their constituent tectons. Furthermore, several distinctive aspects and concepts are described, such as permanent porosity, isostructural (isoreticular) HOFs, and multicomponent mixed ...
Taito Hashimoto, Ichiro Hisaki
wiley +2 more sources
2-Pyridone: monoclinic polymorph
Acta Crystallographica Section E, 2009 The asymmetric unit in the title compound, C5H5NO, comprises two independent but virtually identical molecules of 2-pyridone, and represents a monoclinic polymorph of the previously reported orthorhombic (P212121) form [Penfold (1953). Acta Cryst. 6, 591&
Edward R. T. Tiekink +2 more
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Crystal Engineering of Ionic Cocrystals Sustained by Azolium···Azole Heterosynthons
Pharmaceutics, 2022 Crystal engineering of multi-component molecular crystals, cocrystals, is a subject of growing interest, thanks in part to the potential utility of pharmaceutical cocrystals as drug substances with improved properties. Whereas molecular cocrystals (MCCs)
Maryam Rahmani +3 more
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Synthesis and Reactivity of New 1-Pentafluorophenyl-1Hpyrrole Derivatives
Molecules, 2003 We present 1-pentafluorophenyl-1H-pyrrole and some of its electrophilic substitution reactions: formylation and acetylations. The 2-substituted products formed in these reactions are selectively and in high yield converted into 3-substituted products by ...
Daniel Végh +1 more
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Supramolecular Synthon Identification in Azelaic Acid – Isonicotinamide
Journal of Magnetic Resonance Open, 2022 Supramolecular synthons are the smallest structural units that contain the information inherent in building large molecular assemblies. Here, we apply solid-state NMR methods for the identification of the synthon in a cocrystal of Azelaic acid [(CH2)7(COOH)2]– Isonicotinamide [C6H6N2O]. It is observed that the spin-lattice relaxation time of protons in
Jayasubba Reddy Yarava +4 more
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