Results 151 to 160 of about 44,405 (256)

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation [PDF]

, 2018
Sporadic cases account for 90-95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism.
Abramov, AY, Angelova, PR, Barilani, M, Dossena, M, Gandhi, S, Lazzari, L, Lovejoy, C, Pezzoli, G, Piga, D, Seresini, A, Viganò, M   +10 more
core   +2 more sources

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 97-107, January 2026.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu, Yongsheng Wu, Junyu Qu, Rui Zhu, Wenwen Xu, Jiaxiang Xin, Dawei Wang   +6 more
wiley   +1 more source

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 36-48, January 2026.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases [PDF]

, 2017
Objective: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
,, Bajaj, Nin, Barker, Roger A., Ben-Shlomo, Yoav, Burn, David J., Foltynie, Tom, Grosset, Donald G., Grosset, Katherine A., Hardy, John, Lawton, Michael A., Malek, Naveed, Morris, Huw R., Williams, Nigel M., Wood, Nicholas   +13 more
core   +5 more sources

Quantitative Assessment of Upper Limb Ataxia Using a Virtual Reality‐Based Evaluation System

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 180-192, January 2026.
ABSTRACT Objective Cerebellar ataxia impairs coordination and balance, reducing quality of life. Conventional clinical scales, including the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS), are widely used to assess ataxia but are limited by subjectivity and inter‐rater variability ...
Masayuki Sato, Takayuki Abe, Sho Aoki, Setsuki Tsukagoshi, Yasushi Yuminaka, Yoshio Ikeda   +5 more
wiley   +1 more source

Imaging tau pathology in Parkinsonisms

npj Parkinson's Disease, 2017
The recent development of positron emission tomography radiotracers targeting pathological tau in vivo has led to numerous human trials. While investigations have primarily focused on the most common tauopathy, Alzheimer’s disease, it is imperative that ...
Sarah Coakeley, Antonio P. Strafella
doaj   +1 more source

A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang, Annelies Quaegebeur, Tanrada Pansuwan, Timothy Rittman, Ruiyan Wang, Tuomas PJ Knowles, James B Rowe, David Klenerman, Georg Meisl   +8 more
wiley   +1 more source

Genotype–phenotype interaction in Alzheimer's disease immune activation

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder influenced by genetic factors, particularly related to immune activation. This study examines genotype‐phenotype interactions affecting immune responses in AD as a reaction to neurodegeneration.
Stephanie Knudtzon, Bjørn‐Eivind Kirsebom, Lene Pålhaugen, Francesco Bettella, Berglind Gísladóttir, Shahram Bahrami, Lavinia Athanasiu, Arvid Rongve, Arne Nakling, Ina S. Almdahl, Lisa Kalheim, Jonas Alexander Jarholm, Gøril Rolfseng Grøntvedt, Ragnhild Eide Skogseth, Dag Aarsland, Knut Waterloo, Ole A. Andreassen, Tormod Fladby, Kaja Nordengen   +18 more
wiley   +1 more source

Plasma levels of an N‐terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Tau species lacking truncation of the N‐terminal region, including plasma N‐terminal tau fragment 1 (NT1), have been previously associated with cognitive decline, neurodegeneration, and tau pathology in late‐onset sporadic Alzheimer's disease (AD). METHODS Here, we examined cross‐sectional and longitudinal plasma NT1 as a possible
Stephanie A. Schultz, Yiwen Rao, Lei Liu, Beth Ostaszewski, Amirah K. Anderson, Wai‐Ying Wendy Yau, Zahra Shirzadi, Brian A. Gordon, Jason Hassenstab, John C. Morris, Richard J. Perrin, Ricardo F. Allegri, Nicolas R. Barthélemy, Nick Fox, Gregory S. Day, Mathias Jucker, Allan I. Levey, Johannes Levin, Hiroshi Mori, Stephen Salloway, Peter Schofield, Eric McDade, Reisa A. Sperling, Randall J. Bateman, Dennis J. Selkoe, Jasmeer P. Chhatwal, and the Dominantly Inherited Alzheimer's Network   +26 more
wiley   +1 more source

Alzheimer's disease polygenic risk in early‐ and late‐onset Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The genetic basis of sporadic early‐onset Alzheimer's disease (EOAD) remains largely unknown, prompting evaluation of late‐onset Alzheimer's disease (LOAD) polygenic risk in EOAD. METHODS A LOAD polygenic score (PGS) was calculated in the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS) and Alzheimer's Disease ...
Julian V. Pentchev, Trever Jackson, Naazneen Khan, Thea J. Rosewood, Yen‐Ning Huang, Kwangsik Nho, Andrew J. Saykin, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Meghan Riddle, Steven Salloway, Alireza Atri, Lawrence S. Honig, Erik C. B. Johnson, Raymond Scott Turner, Joseph C. Masdeu, Tatiana M. Foroud, David Clark, Dustin B. Hammers, Jeffrey L. Dage, Kala Kirby, Bernardino Ghetti, Kathy Newell, Chiadi U. Onyike, Gregory S. Day, Neill R. Graff‐Radford, Melissa E. Murray, David T. Jones, Clifford R. Jack Jr., Prashanthi Vemuri, Alexandra Touroutoglou, Ranjan Duara, Ian Grant, Sharon Sha, Thomas S. Wingo, Laurel A. Beckett, Emily Rogalski, Mario F. Mendez, Joel Kramer, Renaud La Joie, Ganna Blazhenets, Lea T. Grinberg, Robert Koeppe, David A. Wolk, Paul Aisen, Rema Raman, Arthur Toga, Walter A. Kukull, Erik Musiek, Kyle B. Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Kelly N. H. Nudelman, for the Longitudinal Early‐Onset Alzheimer's Disease Study Consortium and the Alzheimer's Disease Neuroimaging Initiative   +56 more
wiley   +1 more source