Results 11 to 20 of about 339,095 (200)

Effect of amisulpride, olanzapine, quetiapine, and aripiprazole single administration on c-Fos expression in vasopressinergic and oxytocinergic neurons of the rat hypothalamic supraoptic nucleus

Endocrine Regulations, 2020
Objective. The goal of this study was to reveal the impact of four types of atypical antipsychotics including amisulpride (AMI), olanzapine (OLA), quetiapine (QUE), and aripiprazole (ARI), with different receptor-affinity profile and dissociation ...
Kiss Alexander, Osacka Jana
doaj   +2 more sources

Whole transcriptome organisation in the dehydrated supraoptic nucleus [PDF]

Brazilian Journal of Medical and Biological Research, 2013
The supraoptic nucleus (SON) is part of the central osmotic circuitry that synthesises the hormone vasopressin (Avp) and transports it to terminals in the posterior lobe of the pituitary.
C.C.T. Hindmarch, P. Franses, B. Goodwin, D. Murphy   +3 more
doaj   +5 more sources

Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration. [PDF]

NPJ Aging, 2023
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible
Elsamad G, Mecawi AS, Pauža AG, Gillard B, Paterson A, Duque VJ, Šarenac O, Žigon NJ, Greenwood M, Greenwood MP, Murphy D.   +10 more
europepmc   +2 more sources

Transcriptomic changes in the jerboa supraoptic nucleus during osmotic stress: PCSK1 and PTPRN changes are conserved across desert and mesic species. [PDF]

J Neuroendocrinol
Abstract The supraoptic nucleus (SON) is a hypothalamic region essential for the orchestration of osmoregulation in mammals. We sought to understand how gene expression in the SON is orchestrated in a rodent species adapted for survival in arid desert conditions.
Gillard BT, Amor N, Greenwood MP, Alagaili AN, Murphy D.   +4 more
europepmc   +2 more sources

Supraoptic nucleus morphological features of the hypothalamus in the skin burn injury dynamics

RUDN Journal of Medicine, 2022
Relevance. The relevance of the study of the large cell nucleus of the anterior hypothalamus in case of skin damage is due to the important role of accompanying reactive changes in the neuroendocrine regulatory complex in stress.
Marina A. Samotrueva, Alfiya K. Azhikova
doaj   +1 more source

Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release

Molecular Metabolism, 2023
Objectives: The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome.
Michael P. Greenwood, Mingkwan Greenwood, Soledad Bárez-López, Joe W. Hawkins, Katherine Short, Danijela Tatovic, David Murphy   +6 more
doaj   +1 more source

Neuropeptidomics of the Supraoptic Rat Nucleus [PDF]

Journal of Proteome Research, 2008
The mammalian supraoptic nucleus (SON) is a neuroendocrine center in the brain regulating a variety of physiological functions. Within the SON, peptidergic magnocellular neurons that project to the neurohypophysis (posterior pituitary) are involved in controlling osmotic balance, lactation, and parturition, partly through secretion of signaling ...
Bora, Adriana, Annangudi, Suresh P., Millet, Larry J., Rubakhin, Stanislav S., Forbes, Andrew J., Kelleher, Neil L., Gillette, Martha U., Sweedler, Jonathan V.   +7 more
openaire   +2 more sources

Hypothalamic Neurochemical and Microglial Suppression in Long-Standing Human Hibernation-Like Syndrome. [PDF]

Neuropathol Appl Neurobiol
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Jiang W, Kalsbeek A, Hut RA, Swaab DF, Yi CX.   +4 more
europepmc   +2 more sources

The Hypothalamus of the Beaked Whales: The Paraventricular, Supraoptic, and Suprachiasmatic Nuclei

Biology, 2023
The hypothalamus is the body’s control coordinating center. It is responsible for maintaining the body’s homeostasis by directly influencing the autonomic nervous system or managing hormones. Beaked whales are the longest divers among cetaceans and their
Simona Sacchini, Cristiano Bombardi, Manuel Arbelo, Pedro Herráez   +3 more
doaj   +1 more source

The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain

Molecular Brain, 2023
NLGN4X was identified as a single causative gene of rare familial nonsyndromic autism for the first time. It encodes the postsynaptic membrane protein Neuroligin4 (NLGN4), the functions and roles of which, however, are not fully understood due to the ...
Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki, Atsuo Nakayama   +9 more
doaj   +1 more source