Results 131 to 140 of about 2,251,211 (322)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Quasistatic effective parameters of vibrating elements of electro-acoustic transducers

Archives of Acoustics, 2015
This paper presents an approximate theory of determining effective parameters determining of surface elements of electro-acoustic transducers. It considers the distribution of displacements of these elements due to a steady load.
Andrzej B. DOBRUCKI, Cecylia SZMAL
doaj  

Utilizing Skylab data in on-going resources management programs in the state of Ohio [PDF]

The author has identified the following significant results. The use of Skylab imagery for total area woodland surveys was found to be more accurate and cheaper than conventional surveys using aerial photo-plot techniques.
Baldridge, P. E., Ebbert, T. F., Goesling, P. H., Martin, T. A., Smail, H. E., Stephan, J. G., Wukelic, G. E.   +6 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Interfacial reaction between zirconium alloy and graphite mold/yttrium oxide ceramic mold [PDF]

China Foundry, 2014
Zirconium alloys are active in the molten state and tend to react with the mold during casting. The casting technology of zirconium is not yet well established; especially in selecting the mold materials, which are difficult to determine.
Xie Huasheng, Liu Hongyu, Zhao Jun
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Extending Mohr’s Theory Of Limit States In Determining Soil Seismic Loads On Retaining Walls [PDF]

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2005
Mohr’s theory concerning the stress limit state and its use in determining the active and passive soil pressures on retaining walls is being developed.
N. Ungureanu, Adrian Moga, M. Vrabie
doaj  

Enhancing Manganese Steel Castings: The Role of Magnesium, Calcium, and Surface-Active Elements in Reinforcing Ceramic-Metal Composite Structures

International Journal of Metalcasting
Abstract The enhancement of manganese steel castings through the incorporation of magnesium, calcium, and surface-active elements has been investigated with a focus on improving ceramic-metal composite structures. This study demonstrates that treating the casting surface with magnesium significantly enhances the bond between alumina ceramic ...
Islam Salem, M. K. ElFawkhry, H. M. Abd El-Salam, Mohamed H. Khedr, Mamdouh Eissa, Taha Mattar   +5 more
openaire   +1 more source