Results 31 to 40 of about 363,556 (256)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Effect of Surface-Active Element Oxygen on Heat and Mass Transfer in Laser Welding of Dissimilar Metals: Numerical and Experimental Study

Metals, 2022
The effects of the surface-active element oxygen on the laser welding of 304 stainless steel (304SS) and nickel were numerically and experimentally studied in pure argon and argon–oxygen mixed gas atmospheres containing 21% oxygen (AMO). In this study, the molten pool morphology, thermal behavior, solidification phenomenon, correlation between dilution
Binxin Dong, Zhiyong Li, Gang Yu, Shaoxia Li, Chongxin Tian, Yanhua Bian, Zhuang Shu, Xiuli He   +7 more
openaire   +2 more sources

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Role of Surface-Active Element Sulfur on Thermal Behavior, Driving Forces, Fluid Flow and Solute Dilution in Laser Linear Welding of Dissimilar Metals

Materials, 2023
Understanding heat and mass transfer and fluid flow in the molten pool is very helpful in the selection and optimization of processing parameters, and the surface-active element has an important effect on the heat and mass transfer in laser welding of dissimilar metals.
Zhuang Shu, Gang Yu, Binxin Dong, Xiuli He, Zhiyong Li, Shaoxia Li   +5 more
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

THERMODYNAMICS AND NANOSTRUCTURAL MECHANISMS OF PROCESSES OF MELTING AND CRYSTALLIZATION OF METALS

Литьë и металлургия, 2016
Melting and crystallization of metals are equilibrium thermodynamic processes. As the main structural units of dendrites serve construction nanocrystals which are formed of elementary nanocrystals.
V. Yu. Stetsenko
doaj  

Performance of a Double RIS Communication System Aided by Partially Active Elements

Sensors, 2023
Reconfigurable intelligent surface (RIS) has emerged as a promising technology to enhance the spectral efficiency of wireless communication systems. However, if there are many obstacles between the RIS and users, a single RIS may not provide sufficient ...
Seung-Geun Yoo, Min-A Kim, Jin-Woo Kim, Sang-Wook Park, Young-Hwan You, Hyoung-Kyu Song   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source