Results 101 to 110 of about 1,267,809 (297)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Effects of Surfactant Solubility on the Hydrodynamics of a Viscous Drop in a DC Electric Field

open access: yes, 2020
The physico-chemistry of surfactants (amphiphilic surface active agents) is often used to control the dynamics of viscous drops and bubbles. Surfactant sorption kinetics has been shown to play a critical role in the deformation of drops in extensional ...
Hu, W. -F.   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

open access: yesBeilstein Journal of Nanotechnology, 2014
Human serum albumin nanoparticles have been utilized as drug delivery systems for a variety of medical applications. Since ultra-small superparamagnetic particles of iron oxide (USPIO) are used as contrast agents in magnetic resonance imaging, their ...
Matthias G. Wacker   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Optimization of cleansing oil formulation containing polyglyceryl-6 caprylate and polyglyceryl-4 caprate using the response surface method

open access: yesİstanbul Journal of Pharmacy
Background and Aims: Natural raw materials used in skin cleansing products have recently become popular. In this study, natural-origin raw materials were used to develop an oil-based cleanser formulation with high foaming ability and stable properties ...
Ayşenur Kılıç, Burak Çelik
doaj   +1 more source

Herbicide Adjuvants in Citrus Weed Control

open access: yesEDIS, 2022
Adjuvants are materials added into a herbicide spray mix that improves the herbicide’s performance, especially its handling, application efficacy, and crop-safety.
Ramdas Kanissery
doaj  

Direct and Sensitive Determination of Atropine Sulfate at Polymer Electrode in Presence of Surface Active Agents

open access: yesInternational Journal of Electrochemical Science, 2012
A novel, selective, rapid and simple electrochemical method is demonstrated for the first time for the determination of atropine sulfate, using poly (3, 4-ethylene-dioxythiophene) (PEDOT) electrode film modified platinum electrode in presence of sodium ...
Nada F. Atta   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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