Results 151 to 160 of about 12,679,538 (309)

Demo 13-19 Surface Tension Disc

open access: yes, 2001
A disc connected to a limp spring is lowered onto the surface of water. When it is lifted, the surface tension of the water pulls the disc downward, causing a rather larger extension of the spring than that caused by the weight of the disc alone, as ...

core  

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

open access: yesMolecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

The ManUp Study : physical activity interventions for middle-aged men : a review of what does and does not work

open access: yes, 2011
Physical inactivity is one of the main modifiable risk factors for a range of noncommunicable diseases. Of particular interest are middle-aged men, a hard-to-reach population group for health interventions.
Duncan, Mitch J.   +5 more
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