Results 61 to 70 of about 250,785 (226)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The Next Generation Virgo Cluster Survey (NGVS). III. A Catalog of Surface Brightness Fluctuation Distances and the Three-dimensional Distribution of Galaxies in the Virgo Cluster

The Astrophysical Journal
The surface brightness fluctuation (SBF) method is a robust and efficient way of measuring distances to galaxies containing evolved stellar populations. Although many recent applications of the method have used space-based imaging, SBF remains a powerful
Michele Cantiello, John P. Blakeslee, Laura Ferrarese, Patrick Côté, Gabriella Raimondo, Jean-Charles Cuillandre, Patrick R. Durrell, Stephen Gwyn, Nandini Hazra, Eric W. Peng, Joel C. Roediger, Rúben Sánchez-Janssen, Max Kurzner   +12 more
doaj   +1 more source

Surface Brightness Fluctuations

The Surface Brightness Fluctuation (SBF) method is a powerful tool for determining distances to early-type galaxies. The method measures the intrinsic variance in a galaxy's surface brightness distribution to determine its distance with an accuracy of about 5%.
Cantiello, Michele, Blakeslee, John P.
openaire   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Carnegie Supernova Project I and II: Measurements of H 0 Using Cepheid, Tip of the Red Giant Branch, and Surface Brightness Fluctuation Distance Calibration to Type Ia Supernovae

The Astrophysical Journal
We present an analysis of Type Ia supernovae (SNe Ia) from the Carnegie Supernova Project I and II and extend the Hubble diagram from optical to near-infrared wavelengths ( uBgVriYJH ).
Syed A. Uddin, Christopher R. Burns, M M. Phillips, Nicholas B. Suntzeff, Wendy L. Freedman, Peter J. Brown, Nidia Morrell, Mario Hamuy, Kevin Krisciunas, Lifan Wang, Eric Y. Hsiao, Ariel Goobar, Saul Perlmutter, Jing Lu, Maximilian Stritzinger, Joseph P. Anderson, Chris Ashall, Peter Hoeflich, Benjamin J. Shappee, S. E. Persson, Anthony L. Piro, E Baron, Carlos Contreras, Lluís Galbany, Sahana Kumar, Melissa Shahbandeh, Scott Davis, Jorge Anais, Luis Busta, Abdo Campillay, Sergio Castellón, Carlos Corco, Tiara Diamond, Christa Gall, Consuelo Gonzalez, Simon Holmbo, Miguel Roth, Jacqueline Serón, Francesco Taddia, Simón Torres, Charles Baltay, Gastón Folatelli, Ellie Hadjiyska, Mansi Kasliwal, Peter E. Nugent, David Rabinowitz, Stuart D. Ryder   +46 more
doaj   +1 more source

First Assessment of SDGSAT-1 TIS Thermal Infrared Bands Calibration Using Landsat 9 TIRS-2

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
SDGSAT-1, the inaugural Earth science satellite commissioned by the Chinese Academy of Sciences, successfully lifted off from China's Taiyuan Satellite Launch Center on 5 November 2021. Cross calibration has emerged as an indispensable methodology,
Min Zhu, Qiyao Wang, Jianing Yu, Zhuoyue Hu, Fansheng Chen   +4 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Meausurement of Sky Suface Brightness Fluctuations at lambda = 4 micron [PDF]

Astrophys.J. 580 (2002) 653-662, 2002
We present a Monte-Carlo technique to probe the cosmic Infrared background radiation (CIB) with faint source confusion in deep, wide-field 4 micron images. We report a detection of surface brightness fluctuations using an ensemble of 5000 pixels. The brightness fluctuations do not show correlated structure and appear to be dominated by galaxies.
arxiv   +1 more source

Optical Surface Brightness Fluctuations of Shell Galaxies toward 100 Mpc [PDF]

The Astrophysical Journal, 2008
We measure F814W Surface Brightness Fluctuations (SBF) for a sample of distant shell galaxies with radial velocities ranging from 4000 to 8000 km/s. The distance at galaxies is then evaluated by using the SBF method. For this purpose, theoretical SBF magnitudes for the ACS@HST filters are computed for single burst stellar populations covering a wide ...
Enzo Brocato, I. Biscardi, I. Biscardi, Gabriella Raimondo, Michele Cantiello, Michele Cantiello   +5 more
openaire   +4 more sources