Results 61 to 70 of about 301,544 (297)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Urgent Coronary Artery Bypass Graft Surgery in a Patient with Post-Cardiac Injury Syndrome: A Very Rare Case Report [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023
Background and Objective: Coronary artery bypass surgery in a patient with post-cardiac injury syndrome (PCIS or sever pericarditis following myocardial infarction) is very rare and extremely difficult.
B Askari, K Askari
doaj  

Legendrian and transverse cables of positive torus knots

, 2011
In this paper we classify Legendrian and transverse knots in the knot types obtained from positive torus knots by cabling. This classification allows us to demonstrate several new phenomena.
Etnyre, John B., LaFountain, Douglas J., Tosun, Bulent   +2 more
core   +1 more source

The Schlesinger system and isomonodromic deformations of bundles with connections on Riemann surfaces [PDF]

, 2012
We introduce a way of presentation of pairs $(E,\nabla)$, where $E$ is a bundle on a Riemann surface and $\nabla$ is a logarithmic connection in $E$, which is based on a presentation of the surface as a factor of the exterior of the unit disc.
Artamonov, D. V.
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Estudo da função simpático-adrenal em crianças submetidas a cirurgia cardíaca com hipotermia de superfície, perfusão limitada e parada circulatória Simpathoadrenal function during cardiac surgery in infants using the technique of surface cooling, limited cardiopulmonary bypass and circulatory arrest

Brazilian Journal of Cardiovascular Surgery, 1988
Os níveis de catecolamina plasmática foram medidos em 20 crianças (idade média de 6,00 ± 5,86 meses; peso médio 5,3 ± 1,82 kg), durante a correção de defeitos cardíacos congênitos, usando-se a hipotermia de superfície (26ºC), perfusão cardiopulmonar ...
Richard K Firmin, Paul Bouloux, Paul Allen, Ricardo de Carvalho Lima, J. C Lincoln   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Extracorporeal membrane oxygenation use in open thoracoabdominal aortic aneurysm repair

Journal of Vascular Surgery Cases and Innovative Techniques
Coagulopathy and hypothermia during thoracoabdominal aortic aneurysm (TAAA) repair using cardiopulmonary bypass can contribute significantly to the morbidity of the operation. We used a novel method of venoarterial extracorporeal membrane oxygenation for
Carl T. Schoephoerster, BS, James E. Mace, MD, Mitchell R. Dyer, MD, Kyle Schilling, CCP, Peter J. Rossi, MD   +4 more
doaj   +1 more source

A new ecological mineral-carbonaceous material for adsorption of organic pollutants – a step towards a circular economy [PDF]

Archives of Environmental Protection
Two industrial waste products – namely, cement bypass dust and apple pomace - were used in the synthesis of a new ecological mineral-carbonaceous material intended that can be used for the adsorption of organic pollutants. The raw materials were mixed at
Piotr Słomkiewicz, Sabina Dołęgowska, Katarzyna Piekacz, Dariusz Wideł, Maria Włodarczyk-Makuła   +4 more
doaj   +1 more source