Results 51 to 60 of about 6,317,441 (292)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Gas–solid interface charge characterisation techniques for HVDC GIS/GIL insulators

High Voltage, 2020
Surface charge accumulation on the spacers is one of the key issues restraining the development of HVDC GIS/GIL. The precise measurement of surface charge properties provides the basis for further study of the surface charge transport mechanism as well ...
Lei Zhang, Chuanjie Lin, Chuanyang Li, Simone Vincenzo Suraci, Geng Chen, Uwe Riechert, Uwe Riechert, Tohid Shahsavarian, Masayuki Hikita, Youping Tu, Zhousheng Zhang, Davide Fabiani, Jinliang He, Jinliang He   +13 more
doaj   +1 more source

A simple method considering the synergetic effect of space charge and inhomogeneous material conductivity for DC electric field computation

High Voltage, 2022
The current continuity equation is usually applied to solve DC electric field distribution when there is inhomogeneous material conductivity due to temperature gradient or multi‐layer dielectrics.
Xiao Yang, Yi Zhang, Zhuodong Yang, Hao Dong, Chengrong Li, Bo Qi, Licheng Lu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Charge transport mechanisms in corona charged polymeric materials

, 2013
Polymeric materials have been widely used as an insulator due to their excellent electrical properties, light weight and low cost. Surface potential measurement is one of the simplest and low cost tools to gauge electrical properties of materials.
Zhuang, Yuan
core   +1 more source

Quantifying Electric Charge on Cap-Pin Glass Insulator: Investigating the Impact of Pollution through Simulation and Experimental Approaches

ENP Engineering Science Journal
The objective of this paper is to investigate the behavior of electric charges on cap-pin glass insulator under 50 Hz AC voltage. The study is conducted using COMSOL Multiphysics to understand the charge location, polarity, and parameters affecting their
Rabie Salhi, Abdelouahab Mekhaldi, Madjid Teguar, Omar Kherif   +3 more
doaj   +1 more source

A facile method for producing superhydrophilic glasses via charge injection

AIP Advances, 2018
Superhydrophilic glass has aroused significant interest and attention among researchers because of their excellent performance. A variety of methods by modifying features of the glass such as surface roughness, surface energy, surface chemistry, or ...
Xiangdong Ye, Dongbao Cai, Yuxuan Guo, Junwen Hou   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source