Results 51 to 60 of about 887,698 (266)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Nuclear and Orbital Characterization of the Transition Object (4015) 107P/Wilson–Harrington

The Planetary Science Journal, 2023
Comet 107P/Wilson–Harrington, cross-listed as asteroid 4015, is one of the original transition objects whose properties do not neatly fit into a cometary or asteroidal origin.
Theodore Kareta, Vishnu Reddy
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Electrode Surface Composition of Dual-Intercalation, All-Graphite Batteries

C, 2017
Dual-intercalation batteries implement graphite electrodes as both cathodes and anodes and offer high specific energy, inexpensive and environmentally sustainable materials, and high operating voltages.
Boris Dyatkin, Joseph Halim, Jeffrey A. Read   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Evaluating Atmospheric and Surface Drivers for O2 Variations at Gale Crater as Observed by MSL SAM

The Planetary Science Journal
We explore and evaluate various processes that could drive the variations in the volume mixing ratio (VMR) of atmospheric O _2 observed by the quadrupole mass spectrometer (QMS) of the Sample Analysis at Mars (SAM) instrument suite on the Mars Science ...
Daniel Y. Lo, Sushil K. Atreya, Michael H. Wong, Melissa G. Trainer, Heather B. Franz, Timothy H. McConnochie, Daniel Viúdez-Moreiras, Paul R. Mahaffy, Charles A. Malespin   +8 more
doaj   +1 more source

Trends and drivers of soluble iron deposition from East Asian dust to the Northwest Pacific: a springtime analysis (2001–2017) [PDF]

Atmospheric Chemistry and Physics
Recent shifts in dust emissions and atmospheric compositions in East Asia may have a significant impact on the deposition of soluble iron from dust over the Northwest Pacific (30–50° N, 140° E–160° W).
H. Zhu, H. Zhu, H. Zhu, Y. Liu, Y. Liu, M. Yue, M. Yue, S. Feng, P. Fu, K. Huang, X. Dong, X. Dong, X. Dong, M. Wang, M. Wang   +14 more
doaj   +1 more source

Highly multistable composite surfaces [PDF]

Composite Structures, 2015
Abstract Novel continuous composite surfaces are presented which possess a high degree of multistability. Inspired by the illustrative behaviour of a multistable analog model, we first show how two identical bistable composite shells with tailored asymmetric bistability may be connected to form a continuous quadstable surface.
Cui, Y, Santer, M
openaire   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source