Results 101 to 110 of about 363,241 (312)

Fracture Testing with Surface Crack Specimens [PDF]

open access: yes
Recommendations are given for the design, preparation, and static fracture testing of surface crack specimens. The recommendations are preceded by background information including discussions of stress intensity factors, crack opening displacements, and ...
Orange, T. W.
core   +1 more source

Fatigue crack growth behavior of surface crack in rails

open access: yesProcedia Engineering, 2010
AbstractRolling contact fatigue damages on the surface of rail such as head check, squats are one of growing problems. Since rail fracture can cause derailment with loss of life and property, the understanding of rail fracture mechanisms is important for reducing damages on the surface of rail.
Seo, Jungwon   +3 more
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Predicting failure of specimens with either surface cracks or corner cracks at holes [PDF]

open access: yes
A previously developed fracture criterion was applied to fracture data for surface-cracked specimens subjected to remote tensile loading and for specimens with a corner crack (or cracks) emanating from a circular hole subjected to either remote tensile ...
Newman, J. C., Jr.
core   +1 more source

Method of fabricating an abradable gas path seal [PDF]

open access: yes, 1984
The thermal shock resistance of a ceramic layer is improved. The invention is particularly directed to an improved abradable lining that is deposited on shroud forming a gas path in turbomachinery.
Bill, R. C., Wisander, D. W.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Pengukuran Panjang Simulasi Retak Permukaan dengan Teknik Perambatan Gelombang Ultrasonik Permukaan

open access: yesComTech, 2011
The length measurement of the surface crack simulation using surface ultrasonic wave method is performed for surface crack length of 5, 10, 15, 17.5, 20 and 22.5 mm. Each crack has the orientation of 22.50, 450, 67.50, and 900 against the surface of the
Ashadi Salim
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Investigating the Evolution Law and Fracture Mechanism of Overlying Coal-Bearing Strata Caused by Shallow Multi-Seam Mining in a Gully Area

open access: yesApplied Sciences
Compared with single coal seam mining, the stratum damage induced by shallow multi-seam mining is more severe and poses a risk of mine disasters that threaten the safety of coal mine personnel.
Xiaoshen Xie   +4 more
doaj   +1 more source

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