Results 41 to 50 of about 363,241 (312)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Determination of fracture mechanics parameters structural components with surface crack under thermomechanical loads [PDF]
Scientific Technical Review, 2016 Rotational components of aero engine turbine are the most important components. It operates at high temperature and under conditions of extreme environmental attack such as oxidation, corrosion and wear.
Maksimović Katarina +3 more
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Frontiers in Materials, 2021 It is well established that fatigue crack nucleation and small crack growth in high strength aluminum alloys are highly influenced by the surrounding microstructure including grain boundaries, texture, inclusion barriers, among other factors.
Robert Fleishel +5 more
doaj +1 more source
Effect of grain disorientation on early fatigue crack propagation in face-centred-cubic polycristals: A three-dimensional dislocation dynamics investigation [PDF]
, 2013 Three-dimensional dislocation dynamics simulations are used to study micro-crack interaction with the first micro-structural barrier in face-centred cubic bi-crystals loaded in high cycle fatigue conditions. In the examined configuration, we assumed that
depres, christophe +3 more
core +5 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Frontiers in Earth ScienceStratified rock masses comprise various rocks with different thicknesses, lithologies, and compositions. They exhibit unique cracking morphology and failure modes when subjected to external loads.
Yingjie Xia +7 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Meitan xuebaoIn order to scientifically guide the disaster prevention and ecological environment protection of the gently coal seam mining in the west of Ordos Basin, and to realize the green and safe mining of coal.
Xiaoshen XIE +5 more
doaj +1 more source
Fatigue crack growth in a laser shock peened residual stress field [PDF]
, 2019 Laser Shock Peening is a surface treatment technique used in the aerospace sector to increase fatigue life, as well as resistance to fretting fatigue and stress corrosion cracking.
Achintha +19 more
core +1 more source