Results 61 to 70 of about 54,625 (266)
EnergiesBasin insulator is a critical component of gas-insulated transmission line (GIL) systems. Air gap defects and surface crack defects may form in basin insulators due to casting, installation, or transport processes.
Zhuoran Yang +5 more
doaj +1 more source
Fatigue crack surface area and crack front length: new ways to look at fatigue crack growth
MATEC Web of Conferences, 2018 This paper discusses the appropriateness of crack length as a reference dimension for fatigue damage. Current discussion on short crack versus long crack data is still divided between various approaches to model small crack growth.
van Kuijk Jesse +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Applied Sciences, 2018 Cylindrical structures play an important role in industrial fields. The surface crack is a typical defect in the cylindrical structures. Non-destructive surface crack detection of these structures is critical to the safe operation of the equipment.
Xuekun Liu +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Prediction of Shape Change for Fatigue Crack in a Round Bar Using Three-Parameter Growth Circles
Applied Sciences, 2019 The conventional method for predicting the shape change of a surface crack in a round bar simply utilizes the Paris-Erdogan law with the least squares method using a certain shape assumption with excessive constraints.
Yali Yang, Seokjae Chu, Hao Chen
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Surface crack growth subject to bending and biaxial tension-compression
Fracture and Structural Integrity, 2015 Fatigue surface crack growth and the in-plane and out-of-plane constraint effects are studied through experiments and computations for aluminium alloy D16T.
V. Shlyannikov +3 more
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