Results 41 to 50 of about 276,590 (257)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Advances in Meteorology, 2017 Mesoscale motions are an important factor influencing the applicability of Monin-Obukhov similar theory (MOST) and the surface energy balance. The heterogeneous surface and the vegetation-covered surface also increase the complexity of these two problems.
Yang Guo, Hongchao Zuo
doaj +1 more source
Remote Sensing, 2019 Land cover has a strong effect on the evapotranspiration (ET) and the hydrologic cycle. Urbanization alters the land cover affecting the surface energy balance and ET by, for example, urban encroachment in agricultural areas.
Jie Cheng, William P. Kustas
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Sensors, 2007 Three operative models with minimum input data requirements for estimatingthe partition of available surface energy into sensible and latent heat flux using ASTERdata have been evaluated in a semiarid area in SE Spain.
Juan Puigdefábregas +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Glaciology, 2017 Surface melt in the ablation zone is dominated by atmospheric temperature and surface albedo. We developed a surface mass-balance model with a dynamic component of glacier ice albedo which includes surface properties, clouds and the angle of the sun. The
THOMAS GOELLES, CARL E. BØGGILD
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Micrometeorological conditions and surface mass and energy fluxes on Lewis Glacier, Mt Kenya, in relation to other tropical glaciers [PDF]
The Cryosphere, 2013 The Lewis Glacier on Mt Kenya is one of the best-studied tropical glaciers, but full understanding of the interaction of the glacier mass balance and its climatic drivers has been hampered by a lack of long-term meteorological data.
L. I. Nicholson +3 more
doaj +1 more source