Results 61 to 70 of about 10,767 (294)

Fault Scarp Dating Tool - a MATLAB code for fault scarp dating using in-situ chlorine-36 supplemented with datasets of Yavansu and Kalafat faults

Data in Brief, 2019
We publish a MATLAB code used to analyze concentration profile of cosmogenic 36Cl accumulated in-situ through a rupture history of the fault scarps in western Turkey (Mozafari et al., 2019).
Dmitry Tikhomirov, Nasim Mozafari Amiri, Susan Ivy-Ochs, Vasily Alfimov, Christof Vockenhuber, Naki Akçar   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Discordance between cosmogenic nuclide concentrations in amalgamated sands and individual fluvial pebbles in an arid zone catchment [PDF]

, 2014
Based on cosmogenic 10Be and 26Al analyses in 15 individual detrital quartz pebbles (16–21 mm) and cosmogenic 10Be in amalgamated medium sand (0.25–0.50 mm), all collected from the outlet of the upper Gaub River catchment in Namibia, quartz pebbles yield
Codilean, Alexandru T., Bishop, Paul, Fabel, Derek, Xu, Sheng, Fenton, Cassandra R.   +4 more
core   +1 more source

Deglaciation of the Colorado Rocky Mountains following the Last Glacial Maximum

Cuadernos de Investigación Geográfica, 2017
The availability of almost 180 cosmogenic-radionuclide (CRN) surface-exposure ages from moraine boulders and glacially polished bedrock surfaces makes possible an assessment of the timing and character of the local Last Glacial Maximum (LLGM) and ...
E.M. Leonard, B.J.B. Laabs, A.D. Schweinsberg, C.M. Russell, J.P. Briner, N.E. Young   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Surface exposure dating of non-terrestrial bodies using optically stimulated luminescence: A new method [PDF]

, 2012
We propose a new method for in situ surface exposure dating of non-terrestrial geomorphological features using optically stimulated luminescence (OSL); our approach is based on the progressive emptyingof trapped charge with exposure to light at depth ...
Jain, Mayank, Sohbati, Reza, Murray, Andrew   +2 more
core   +1 more source

A Model Framework for Scaling Pre‐Quaternary Cosmogenic Nuclide Production Rates

Geochemistry, Geophysics, Geosystems
Cosmogenic nuclide dating is an essential component of studying Earth surface processes, but it requires knowledge of how nuclide production rates vary in time and space.
M. Mijjum, K. E. Bristol, R. K. Bono, C. J. Sprain, N. Lifton, M. M. Tremblay   +5 more
doaj   +1 more source

Cosmogenic ³He exposure dating in mafic rocks by “Virtual mineral separation” of pyroxene [PDF]

Geochronology
We describe a “virtual mineral separation” method for measuring the cosmogenic 3He concentration in pyroxene in mafic rocks that consist mainly of plagioclase and pyroxene, without physically separating the minerals. This approach is significantly faster
M. Bergelin, M. Bergelin, G. Balco, G. Balco, R. A. Ketcham   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source