Results 101 to 110 of about 16,702 (269)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Relative importance of uncertain model parameters driving water fluxes in a Land Surface Model

Journal of Hydrology
Abstract. We focus on the way temporal distributions of key components of the water cycle are influenced by typically uncertain parameters embedded in a Land Surface Model. We rest on a joint analysis of multiple global sensitivity metrics to provide a comprehensive assessment of the ranking of the relative importance of uncertain factors of various ...
Aronne Dell’Oca, David Luttenauer, Alberto Guadagnini, Sylvain Weill, Philippe Ackerer   +4 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Assessing the impact of carbonitriding on residual weld hydrogen in the manufacture of a gear component

Journal of Materials Science: Materials in Engineering
In this paper, we report on the direct measurement of hydrogen flux from a machined car gear component immediately following carbonitriding treatment and prior to its welding to the gear train.
Fernando Bonilla-Angulo, Tiago Castelão, Yvan Chastel, Frank W. H. Dean, Catherine E. Gardner, Gildas Lecuyer   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Modelling and optimisation of the surface‐mounted permanent magnet machine with multi‐level array magnets

IET Electric Power Applications
An analytical and optimisation method is presented to improve the air‐gap magnetic field of the surface‐mounted permanent magnet machine with multi‐level array magnets, which can reduce air‐gap magnetic field harmonics and torque ripple.
Longxuan Li, Zhaoliang Chen, Wenliang Zhao, Chengwu Diao, Byung‐il Kwon   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Modification of Surface Fluxes from Component Models in Global Coupled Models

Journal of Climate, 1997
Abstract The present generation of global coupled ocean–atmosphere GCMs contains considerable systematic errors both in terms of net surface heat flux and simulated SSTs. Here, a global coupled GCM is used to illustrate how systematic errors in the separate coupled model components (atmosphere and ocean) contribute to the simulations of net surface ...
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source