Results 71 to 80 of about 6,734,388 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The impact of clearing for agriculture on the surface energy budget [PDF]

, 1996
A simple model is developed to analyse the surface energy balance from satellite observations for south-western Australia. This illustrates that the replacement of native vegitation with agriculture based on a winter growing annual species has led to a ...
Xinmei, H., Smith, R.C.G., Lyons, T.J., R. C. G. SMITH, HUANG XINMEI, T. J. LYONS   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Is there 1.5-million-year-old ice near Dome C, Antarctica? [PDF]

The Cryosphere, 2017
Ice sheets provide exceptional archives of past changes in polar climate, regional environment and global atmospheric composition. The oldest dated deep ice core drilled in Antarctica has been retrieved at EPICA Dome C (EDC), reaching ∼ 800 000 
F. Parrenin, M. G. P. Cavitte, M. G. P. Cavitte, D. D. Blankenship, J. Chappellaz, H. Fischer, O. Gagliardini, V. Masson-Delmotte, O. Passalacqua, C. Ritz, J. Roberts, J. Roberts, M. J. Siegert, D. A. Young   +13 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Thermal Modelling of the Ventilation and Cooling inside Axial Flux Permanent Magnet Generators [PDF]

, 2010
Axial flux permanent magnet generators are of particular interest for power generation in harsh and confined conditions. Due to their compactness and high power density, the ventilation and cooling inside axial flux permanent magnet generators have ...
LIM, CHIN,HONG, Lim, Chin Hong
core  

Land-Atmosphere Transfer Parameters in the Brazilian Pantanal during the Dry Season

Atmosphere, 2015
The Brazilian region of Pantanal is one of the largest wetlands in the world, characterized by a wet season, in which it is covered by a shallow water layer, and a dry season, in which the water layer disappears.
Paolo Martano, Edson Pereira Marques Filho, Leonardo Deane de Abreu Sá   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source