Results 261 to 270 of about 6,390,963 (305)

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Fate of heat approaching the Filchner-Ronne Ice Shelf mediated by continental shelf eddies. [PDF]

Sci Adv
Stewart AL, Youngs MK, Prend CJ.
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Climatic reach of small-scale turbulence in the ocean interior. [PDF]

Nat Commun
Cimoli L, Mashayek A, Naveira Garabato AC, Caulfield CP, Alford MH, Baker L, Cael BB, Fernández Castro B, de Lavergne C, Ellison E, Gebbie G, Gula J, Heimbach P, Lanham J, Le Boyer A, Oglethorpe K, Peltier WR, Pillar HR, Piotrowski AM, Purkey SG, Reynard N, Shuckburgh E, Siegert MJ, Silvano A, Skinner LC, Spingys CP, Talley LD, Taylor JR, Voet G, Williams RG, Wilson C, Wynne-Cattanach BL.   +31 more
europepmc   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

The effect of impact location, velocity, and frequency on head injury criterion during ice hockey helmet drop tests. [PDF]

PeerJ
Lin R, Hu H, Du T, Zhou X, Wang R, Wan X.   +5 more
europepmc   +1 more source

Suspended particles for omnidirectional template sacrifice for rapid vascular patterning within engineered tissues. [PDF]

Sci Adv
Malkani S, Prado O, Kang I, Stevens KR.
europepmc   +1 more source

Stochastic cloud fluctuations drive Arctic winter radiative bistability. [PDF]

Sci Adv
Lim JS, Feingold G.
europepmc   +1 more source

The in-stream renewable energy potential of rivers for remote communities in the global Arctic. [PDF]

Nat Commun
Kirby K, Rennie CD, Nistor I, Johnstone C, Ordoñez-Sánchez S, Fu S, Cousineau J, Shilton H.   +7 more
europepmc   +1 more source

Ice-phase optothermal tweezers. [PDF]

Nat Commun
Zhou J, Peng Y, Du P, Chen Z, Zhang J, Jin Z, Dai X, Ji Y, Wang M, Wang Y, Zheng Y, Chen J, Qu J, Shao Y.   +13 more
europepmc   +1 more source