Results 131 to 140 of about 144,391 (309)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Active Control of complex surface impedance
, 2009 Hybrid (active / passive) absorbers are developed at the LMFA mainly as wall treatments of flow ducts. Active control is used to increase the absorption of a porous layer at low frequencies by cancelling the imaginary part of the surface impedance ...
Marie-annick Gall +2 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A novel technique for evaluating the degradation of engine components non-destructively
, 2002 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Impedance spectroscopy (IS) was used to evaluate the microstructural changes of a thermally-grown oxide (TGO) layer on a nickel-based superalloy or bond ...
Ali, Md Shawkat
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Safe Acting and Manipulation in Human Environments: A Key Concept for Robots in our Society
, 2012 In this paper we review our work on safe acting and manipulation in human environments. In order for a robot to be able to safely interact with its environment it is primary to be able to react to unforeseen events in real-time on basically all levels of
Hirzinger, Gerd +4 more
core
Известия высших учебных заведений России: Радиоэлектроника, 2015 The impedance load structure, based on slots in the parallel plate waveguide wall is considered in order to determine the equivalent surface impedance.
V. G. Koshkid’Ko, O. V. Alpatova
doaj