Results 61 to 70 of about 1,010,016 (265)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Metals, 2019 Series of super-hard ceramic layers have been successfully developed on high carbon steels, with a significant improvement of corrosion resistance and hardness, without changing the original properties, which were derived from mixtures of slag (electric ...
Wilson Handoko +2 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Analysis of Fragmentation Phenomenon of Composite Layers of Fe-TiC Type Obtained “in situ” in Steel Casting [PDF]
Archives of Foundry EngineeringA method for fabrication of a composite layer on the surface of a steel casting using coating containing TiC substrates was presented. The reaction of the synthesis of the ceramic phase was based on the SHS method (Self-propagating High-temperature ...
J. Marosz, S. Sobula
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Capacity Decay Mechanism of the LCO + NMC532/Graphite Cells Combined with Post-Mortem Technique
Energies, 2017 Lithium ion batteries are widely used in portable electronics and transportations due to their high energy and high power with low cost. However, they suffer from capacity degradation during long cycling, thus making it urgent to study their decay ...
Linjing Zhang +2 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Post-processing of engineering products obtained by additive layer modelling
Технічна інженеріяThe article investigates the influence of mechanical post-treatment on the geometric and physical and mechanical characteristics of products manufactured by additive layer modelling (in particular, FDM). The mechanisms of formation of the defective layer
V.M. Orel +3 more
doaj +1 more source