Results 81 to 90 of about 1,319,702 (316)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analysis of Fragmentation Phenomenon of Composite Layers of Fe-TiC Type Obtained “in situ” in Steel Casting [PDF]

Archives of Foundry Engineering
A method for fabrication of a composite layer on the surface of a steel casting using coating containing TiC substrates was presented. The reaction of the synthesis of the ceramic phase was based on the SHS method (Self-propagating High-temperature ...
J. Marosz, S. Sobula
doaj   +1 more source

Tailored Surface Engineering of Pigments by Layer-by-Layer Coating [PDF]

, 2015
We have evaluated the feasibility of layer-by-layer encapsulation technology for the improvement of dye pigments used for tattoos or permanent make-up. The formation of core-shell structures is possible by coating pigments with thin films of several different polyelectrolytes using this technology. The physicochemical surface properties, such as charge
Lars, Dähne, Julia, Schneider, Dirk, Lewe, Henrik, Petersen   +3 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Capacity Decay Mechanism of the LCO + NMC532/Graphite Cells Combined with Post-Mortem Technique

Energies, 2017
Lithium ion batteries are widely used in portable electronics and transportations due to their high energy and high power with low cost. However, they suffer from capacity degradation during long cycling, thus making it urgent to study their decay ...
Linjing Zhang, Jiuchun Jiang, Weige Zhang   +2 more
doaj   +1 more source

Surface Diffusion and Surface Layer in Ceramics

Hyomen Kagaku, 1984
Methods of measuring surface diffusion coefficients and related phenomena have been reviewed. These include grain boundary grooving, sinusoidal profile decay, isolated scratch decay, tracer, 18O-exchange reaction, sintering, spheroidization of cylindrical voids, work function, etc.
Yasuro IKUMA, Wazo KOMATSU
openaire   +2 more sources

Composite hodographs and inertial oscillations in the nocturnal boundary layer

, 2011
In this work the dynamic behaviour of the wind in the nocturnal boundary layer is studied, with a particular focus on systematic behaviour of the near-surface wind.
P. Baas, Wiel, BJH Bas van de, L. van den Brink, A.A.M. Holtslag, Baas, P, van den Brink, L., Wiel, B.J.H., van de, van de Wiel, B.J.H., Wiel, van de, B.J.H., Holtslag, AAM, Holtslag, A.A.M., B. J. H. van de Wiel, Baas, P., Brink, L van den, Brink, van den, L., Brink, L., van den   +15 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source