Results 91 to 100 of about 793,915 (265)

Disproportionate Soil Inorganic Carbon Loss and Associated CO2 Emission Driven by Soil Acidification

Earth's Future
Soil acidification induced by nitrogen fertilization and atmospheric deposition is widely assumed to deplete soil inorganic carbon (SIC), thereby generating substantial CO2 emissions that amplify climate warming.
Qiongyu Zhang, Jianxing Zhu, Qiufeng Wang, Tianxiang Hao, Rolf David Vogt, Marcos Fernández‐Martínez, Yue Xi, Quanhong Lin, Yanran Chen, Nianpeng He, Guirui Yu, Cong‐Qiang Liu   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

THE SURFACE NETWORK

Building a permanent lunar base requires more than isolated missions and heroic vehicles. It needs infrastructure. This paper proposes the Surface Network: an energy, logistics, and data network built on the Moon itself by interconnecting the landers as they arrive.
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Glacier Coverage Dominates the Response of Runoff and Its Components to Climate Change in the Tianshan Mountains

Water Resources Research
In the context of climate warming, runoff changes in the Tianshan Mountains vary widely across basins, with both increasing and decreasing trends. However, the underlying mechanisms remain to be elucidated due to the complexity of the response of runoff ...
Zelong Yang, Peng Bai, Yuan Tian, Xiaomang Liu   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Irrigated agriculture on the southern and northern slopes of the Tianshan Mountains faces different risks of water scarcity

Advances in Climate Change Research
Irrigated agriculture dependent on runoff from the Tianshan Mountains underpins socioeconomic development in the arid regions of Central Asia. However, ongoing warming and agricultural expansion profoundly alter local water supply and demand.
Ze-Long Yang, Peng Bai, Kai-Wen Wang, Yuan Tian, Xiao-Mang Liu   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Polymer networks at surfaces

, 2003
In this thesis the formation and properties of a polymer gel on and at a surface are investigated. The gel under investigation is defined as a three-dimensional network of "phantom" macromolecules that form permanent links with one another and also with confining planar surfaces.
openaire   +2 more sources