Results 81 to 90 of about 793,915 (265)

Reactions on Surfaces with Neural Networks

, 2001
An understanding of the underlying mechanisms of surface reactions, e.g., the poisoning or promotion of dissociative adsorption of molecules by adsorbates, is of strong technological relevance. Molecular dynamics (MD) simulations of adsorption processes with extensive statistics can require to evaluate the potential-energy and the forces acting on the ...
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Biomass Carbon Sequestration Potential in China's Drylands

Earth's Future
Drylands are important carbon pools for climate change mitigation but remain highly vulnerable to climate and anthropogenic pressures. Despite China hosting one of the largest dryland areas globally, limited studies have quantified its biomass carbon ...
Zimin Tan, Shuai Wang, Fangli Wei, Changjia Li, Fengyu Fu, Lixin Wang   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

On Invariant Surfaces in Gene Network Models

Journal of Applied and Industrial Mathematics, 2020
Summary: We construct an invariant two-dimensional surface in the phase portrait of a certain six-dimensional dynamical system which is considered as a model for the circular gene network functioning. This invariant surface contains an equilibrium point \(S_0\) of the system, and if \(S_0\) is hyperbolic then this surface contains a cycle of the system.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Impact of Network Geometry on Large Networks With Intelligent Reflecting Surfaces

IEEE Transactions on Vehicular Technology
In wireless networks assisted by intelligent reflecting surfaces (IRSs), jointly modeling the signal received over the direct and indirect (reflected) paths is a difficult problem. In this work, we show that the network geometry (locations of serving base station, IRS, and user) can be captured using the so-called triangle parameter $Δ$. We introduce a
Konpal Shaukat Ali, Martin Haenggi, Arafat Al-Dweik, Marwa Chafii   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An Evapotranspiration Assimilation Method Based on Ensemble Kalman Filter and À Trous Wavelet

Advances in Meteorology, 2013
It is challenging to assimilate the evapotranspiration product (EP) retrieved from satellite data into land surface models (LSMs). In this paper, a perturbed ensemble Kalman filter (PEKF) and à trous wavelet transform (AWT) integrated method are proposed
Shaohui Chen, Jianwei Qi, Xiaomin Sun, Xiangzheng Deng, Jing Tian   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source