Results 221 to 230 of about 5,652,788 (287)

In Vitro Characterization of Agonist and Antagonist Peptide Binding Interaction Kinetics to GLP-1R in HEK293T Cells Using Surface Plasmon Resonance Microscopy. [PDF]

ACS Med Chem Lett
A Thirumurthy M, Aguilar Díaz de León JS, Pan S, Ly N.   +3 more
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Development of an Aptamer-Based Surface Plasmon Resonance Biosensor for Detecting Chloramphenicol in Milk. [PDF]

Biosensors (Basel)
Qi M, Xia N, Wang X, Wang X, Chen H, Lv D, Cao Y.   +6 more
europepmc   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

Surface Plasmon Resonance Imaging and Microscopy Modalities for Information-Rich, Label-Free Analysis of Biomolecular Interactions and Disease Biomarkers. [PDF]

Chem Biomed Imaging
Hanson VA, Van Zant W, Ebel CP, Malinick AS, Stuart DD, Stemple LN, Cheng Q.   +6 more
europepmc   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Thermally Regulated Methanol Selectivity in Photo‐Thermo Methane Oxidation Through Interfacial Methyl Transfer

Advanced Science, EarlyView.
Photo‐thermo cascade catalysis enables highly selective methane‐to‐methanol conversion over Au‐ZnO, achieving a CH3OH production rate of ∼800 µmol h−1 with 86% selectivity. Thermal activation gates the transfer of methane‐derived methyl intermediates from ZnO to Au, thereby redirecting the reaction pathway toward methanol formation. ABSTRACT The direct
Youxun Xu, Chengzhi Guo, Chaoran Jiang, Leirun Chen, Juncong Wang, Enqi Chen, Yang Lan   +6 more
wiley   +1 more source

Enhancing angular photonic spin Hall effect at surface plasmon resonance. [PDF]

Nanophotonics
Olaya CM, Hayazawa N, Balgos MH, Tanaka T.   +3 more
europepmc   +1 more source

Metasurface‐Based Multidimensional Light‐Field Manipulation: From Technologies to Applications

Advanced Science, EarlyView.
Multidimensional metasurfaces enable versatile manipulation of multiple optical degrees of freedom, including phase, amplitude, polarization, wavelength, and orbital angular momentum. This review summarizes their fundamental mechanisms, emerging strategies for multidimensional light‐field control, and key applications in optical computing, imaging ...
Heliang Yin, Shuo Sun, Jiahao Zhang, Jianuo Hu, Yubin Qiao, Liang Chen, Jin Li   +6 more
wiley   +1 more source

A novel surface plasmon resonance approach to assess anti-dsDNA antibody kinetics and disease severity in systemic lupus erythematosus. [PDF]

Clin Transl Immunology
Nagant C, Taghavi M, Ziani HBK, Ghorra N, Badot V, Parmentier S, Corazza F.   +6 more
europepmc   +1 more source