Results 101 to 110 of about 5,309,323 (231)

Multiplex biosensor immunoassays for antibiotics in the food chain [PDF]

, 2009
The use of antibiotics in food-producing animals may result in unwanted residues in food products. The main objective of the present research was to study the development and application of fast and automated multiplex surface plasmon resonance (SPR ...
Haasnoot, W.
core  

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

PERANCANGAN SET UP INSTRUMEN BIOSENSOR SURFACE PLASMON RESONANCE (SPR)

JURNAL HADRON
Telah dilaksanakan penelitian skripsi dengan judul perancangan set up instrumen biosensor surface plasmon resonance (SPR) yang bertujuan untuk membuat perancangan intensitas cahaya terhadap sudut dan untuk mengetahui aktivitas molekul SPR dengan menggunakan Metode Krestcmann.
Ginting, Hijrahanisa, Fadlly, T. Andi, Fahril, M. Ari   +2 more
openaire   +2 more sources

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Characterizing the physicochemical properties of magnetic nanoparticles by a surface plasmon resonance approach

AIP Advances
Magnetic nanoparticles (MNPs) are widely recognized as effective signal amplifiers for surface plasmon resonance (SPR)-based biosensors. Herein, we report that SPR sensors can be a useful tool to characterize the physicochemical properties of surface ...
Shahriar Mostufa, Bahareh Rezaei, Ebrahim Azizi, Yongqiang Andrew Wang, Changzhi Li, Jenifer Gómez-Pastora, Rui He, Kai Wu   +7 more
doaj   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Plasmonic propagations distances for interferometric surface plasmon resonance biosensing

Nanoscale Research Letters, 2011
A surface plasmon resonance (SPR) scheme is proposed in which the local phase modulations of the coupled plasmons can interfere and yield phase-sensitive intensity modulations in the measured signal.
Lepage Dominic, Carrier Dominic, Jiménez Alvaro, Beauvais Jacques, Dubowski Jan   +4 more
doaj  

A Portable Gold-Nanoparticle-Enhanced Surface Plasmon Resonance Sensor for Highly Sensitive β-Bungarotoxin Quantification in Snake Poisoning Diagnosis

Proceedings
This study introduces a portable gold-nanoparticle-enhanced surface plasmon resonance (SPR) biosensor for the swift and highly sensitive detection of β-bungarotoxin in krait venom.
Samuel Husin Surya Mandala, Mochamad Januar, Chien-Chun Liu, Jau-Song Yu, Kou-Chen Liu   +4 more
doaj   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source