Results 91 to 100 of about 74,393 (324)

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source

Pengaruh Konsentrasi AgNO 3 dan Suhu Sintesis terhadap Surface Plasmon Resonance (SPR) Nanopartikel Perak

open access: yesIndonesian Journal of Chemical Research, 2016
The research aims to synthesis of silver nanoparticles (AgNPs) via bio-reduction method using mangosteen skin extract. The growth of AgNPs was characterized by ultraviolet-visible spectroscopy (UV-Vis).
Irwan R, Muhammad Zakir, Prastawa Budi
doaj  

Sensitivity enhancement of surface plasmon resonance sensors with 2D franckeite nanosheets

open access: yesResults in Physics, 2019
As a latest novel two-dimensional (2D) material with naturally occurring van der Waals heterostructure, franckeite has the unique advantages compared with the artificial stacking heterostructures.
Shuaiwen Gan   +3 more
doaj   +1 more source

Surface plasmon resonance biosensors for highly sensitive detection in real samples [PDF]

open access: yes, 2009
In this work we summarize the main results obtained with the portable surface plasmon resonance (SPR) device developed in our group (commercialised by SENSIA, SL, Spain), highlighting its applicability for the real-time detection of extremely low ...
Carrascosa, L. G.   +5 more
core   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

Gold Nanoplates for a Localized Surface Plasmon Resonance-Based Boric Acid Sensor

open access: yesSensors, 2017
Localized surface plasmon resonance (LSPR) properties of metallic nanostructures, such as gold, are very sensitive to the dielectric environment of the material, which can simply be adjusted by changing its shape and size through modification of the ...
Marlia Morsin   +3 more
doaj   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

open access: yesAdvanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo   +7 more
wiley   +1 more source

Simultaneous surface acoustic wave and surface plasmon resonance measurements: electrodeposition and biological interactions monitoring

open access: yes, 2003
We present results from an instrument combining surface acoustic wave (SAW) propagation and surface plasmon resonance (SPR) measurements. The objective is to use two independent methods, the former based on adsorbed mass change measurements and the ...
Campitelli, A.   +5 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

open access: yesAdvanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu   +15 more
wiley   +1 more source

MicroRNA detection on microsensor arrays by SPR imaging measurements with enzymatic signal enhancement. [PDF]

open access: yes, 2019
We investigated sequence-specific and simultaneous microRNA (miRNA) detections by surface plasmon resonance (SPR) imaging measurements on SPR chips possessing an Au spot array modified with probe DNAs based on a miRNA-detection-selective SPR signal ...
Aoki, Hiroshi   +2 more
core  

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