Results 71 to 80 of about 5,685,494 (281)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

A Highly Sensitive Coreless Fiber SPR Sensor Based on Au/TiO₂ Hyperbolic Metamaterials

Chemosensors
In this work, we propose a hyperbolic metamaterials (HMMs)-based coreless fiber surface plasmon resonance (SPR) sensor. Leveraging the absence of a core in coreless fibers, the evanescent waves at the cladding–external solution interface couple more ...
Fang Wang, Qiwei Guo, Jintao Cai, Lening Sun, Lin Zhang, Xuewen Shu   +5 more
doaj   +1 more source

Fano Resonance Enhanced Surface Plasmon Resonance Sensors Operating in Near-Infrared

Photonics, 2018
In the phase-sensitivity-based surface plasmon resonance (SPR) sensing scheme, the highest phase jump usually happens at the darkness or quasi-darkness reflection point, which results in low power for detection.
Tianye Huang, Shuwen Zeng, Xiang Zhao, Zhuo Cheng, Perry Ping Shum   +4 more
doaj   +1 more source

Preparation of Stable Gold Colloids for Sensitivity Enhancement of Progesterone Immunoassay using Surface Plasmon Resonance [PDF]

, 2007
The purpose of this study was to prepare concentrated and stable gold colloids for the enhancement of the signal response of the SPR technique for detecting small molecules such as progesterone.
Wu, Kevin Su-Wei
core  

A field-deployed surface plasmon resonance (SPR) sensor for RDX quantification in environmental waters [PDF]

, 2017
A field-deployable surface plasmon resonance (SPR) sensor is reported for the detection RDX at ppb concentration in environmental samples.
Havard, Thierry, Thibault Brulé, Clarisse Deschênes-Rancourt, Granger, Geneviève, Martel, Richard, Geneviève Granger, Thierry Havard, Andreea R. Schmitzer, Natalia Bukar, Bukar, Natalia, Masson, Jean-Francois, Brulé, Thibault, Richard Martel, Deschênes-Rancourt, Clarisse, Jean-Francois Masson, Schmitzer, Andreea R.   +15 more
core   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Surface Plasmon Resonance (SPR) [PDF]

, 2015
  +5 more sources

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Gold Nanoplates for a Localized Surface Plasmon Resonance-Based Boric Acid Sensor

Sensors, 2017
Localized surface plasmon resonance (LSPR) properties of metallic nanostructures, such as gold, are very sensitive to the dielectric environment of the material, which can simply be adjusted by changing its shape and size through modification of the ...
Marlia Morsin, Muhamad Mat Salleh, Akrajas Ali Umar, Mohd Zainizan Sahdan   +3 more
doaj   +1 more source