Results 121 to 130 of about 118,586 (322)

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Characterizing the physicochemical properties of magnetic nanoparticles by a surface plasmon resonance approach

AIP Advances
Magnetic nanoparticles (MNPs) are widely recognized as effective signal amplifiers for surface plasmon resonance (SPR)-based biosensors. Herein, we report that SPR sensors can be a useful tool to characterize the physicochemical properties of surface ...
Shahriar Mostufa, Bahareh Rezaei, Ebrahim Azizi, Yongqiang Andrew Wang, Changzhi Li, Jenifer Gómez-Pastora, Rui He, Kai Wu   +7 more
doaj   +1 more source

Fenpicoxamid-Imprinted Surface Plasmon Resonance (SPR) Sensor Based on Sulfur-Doped Graphitic Carbon Nitride and Its Application to Rice Samples. [PDF]

Micromachines (Basel), 2023
Akıcı ŞY, Bankoğlu Yola B, Karslıoğlu B, Polat İ, Atar N, Yola ML.   +5 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

High sensitivity refractive index sensor based on surface plasmon resonance with topological insulator

Results in Physics, 2019
A high sensitivity refractive index sensor based on surface plasmon resonance (SPR) with topological insulator (Bi2Te3) has been proposed theoretically. It is demonstrated that the presented sensor exhibits an extremely great sensitivity enhancement with
Yuting Zhao, Shuaiwen Gan, Guanghua Zhang, Xiaoyu Dai   +3 more
doaj   +1 more source

Erratum: Correction Notice: Establishment of Human PD-1/PD-L1 Blockade Assay Based on Surface Plasmon Resonance (SPR) Biosensor. [PDF]

Bio Protoc, 2023
Puopolo T, Li H, Gutkowski J, Cai A, Seeram NP, Ma H, Liu C.   +6 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Plasmonic propagations distances for interferometric surface plasmon resonance biosensing

Nanoscale Research Letters, 2011
A surface plasmon resonance (SPR) scheme is proposed in which the local phase modulations of the coupled plasmons can interfere and yield phase-sensitive intensity modulations in the measured signal.
Lepage Dominic, Carrier Dominic, Jiménez Alvaro, Beauvais Jacques, Dubowski Jan   +4 more
doaj  

Establishment of Human PD-1/PD-L1 Blockade Assay Based on Surface Plasmon Resonance (SPR) Biosensor. [PDF]

Bio Protoc, 2023
Puopolo T, Li H, Gutkowski J, Cai A, Seeram NP, Ma H, Liu C.   +6 more
europepmc   +1 more source

Insect diversity and composition during the wet and dry seasons in three forest types of Johor, Malaysia [PDF]

, 2015
The insect diversity and abundance in three forest types namely: Endau Rompin (pristine lowland forest) Gunung Ledang (pristine highland forest) and Bukit Soga (degraded lowland forest) in Johor, Malaysia were studied.
Siddiki, Aishatu
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