Results 211 to 220 of about 2,403,906 (294)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Absolute ion hydration free energy scale and the surface potential of water via quantum simulation. [PDF]

Proc Natl Acad Sci U S A, 2020
Shi Y, Beck TL.
europepmc   +1 more source

Identification of naturally presented HLA ligands on the surface of healthy and malignant hematopoetic cells and their therapeutic potential as targets for TCR-transgenic T cells

, 2015
Richard Klar
openalex   +1 more source

Theoretical study of the potential energy surface and differential scattering cross sections of He-HI complex

, 2007
YU Chun-ri, Eryin Feng, Xinlu Cheng, Yang Xiang-Dong, (1)安徽师范大学物理系,芜湖 241000; (2)安庆师范学院物理与电气工程学院,安庆 246011;安徽师范大学物理系,芜湖 241000;四川大学原子与分子物理研究所,成都 610065; (3)四川大学原子与分子物理研究所,成都 610065   +4 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport. [PDF]

Transl Vis Sci Technol, 2020
Pasricha ND, Smith AJ, Levin MH, Schallhorn JM, Verkman AS.   +4 more
europepmc   +1 more source

Finding intersections between electronic excited state potential energy surfaces with simultaneous ultrafast X-ray scattering and spectroscopy

, 2019
Kasper S. Kjær, Tim B. van Driel, Tobias Harlang, Kristjan Kunnus, Elisa Biasin, Kathryn Ledbetter, Robert W. Hartsock, Marco Reinhard, Sergey Koroidov, Lin Li, Mads G. Laursen, Frederik B. Hansen, Peter Vester, Morten Christensen, Kristoffer Haldrup, M. Nielsen, Asmus Ougaard Dohn, Mátyás Pápai, Klaus B. Møller, Pavel Chábera, Yizhu Liu, H. Tatsuno, Cornelia Timm, Martin Jarenmark, Jens Uhlig, Villy Sundstöm, Kenneth Wärnmark, Petter Persson, Zoltán Németh, Dorottya Sárosiné Szemes, Éva G. Bajnóczi, György Vankó, Roberto Alonso‐Mori, James M. Glownia, S. Nelson, Marcin Sikorski, Dimosthenis Sokaras, Sophie E. Canton, H. Lemke, Kelly J. Gaffney   +39 more
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time. [PDF]

Biophys J, 2020
Burtscher V, Hotka M, Freissmuth M, Sandtner W.   +3 more
europepmc   +1 more source