Results 71 to 80 of about 11,501,247 (301)

Surface properties of Chlamydia psittaci [PDF]

Infection and Immunity, 1980
The surface properties of elementary bodies of Chlamydia psittaci were investigated by diethylaminoethyl-Sephadex chromatography, cytophoresis, partitioning in an aqueous polymer two-phase system, and hydrophobic interaction chromatography of the organism. The surface of C. psittaci was found to be hydrophobic and negatively charged at pH 7 and to have
D W, Vance, T P, Hatch
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Surface properties and susceptibility to staining of a resin composite after brushing with different whitening toothpastes [PDF]

Restorative Dentistry & Endodontics
Objectives This study investigated the effects of different whitening toothpaste (WT) on the surface properties and staining susceptibility of a resin composite.
Aline da Silva Barros, Carolina Meneghin Barbosa, Renata Siqueira Scatolin, Waldemir Francisco Vieira Junior, Laura Nobre Ferraz   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Frictional Properties of a Surface Covered With Soft Metal Surface Film (Surface Topography and Frictional Properties)

Journal of Tribology, 1986
The friction between a real engineering surface composed of many micro-asperities and a surface covered with soft metal film is discussed. First, the frictional coefficient shows a remarkable load dependency, when a hard single protuberance with a small radius of curvature is slid on a soft metal surface.
KATO, Shinobu, MARUI, Etsuo, TACHI, Kiyoo   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers [PDF]

, 2012
This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer).
Hassan Larhrib (2076589), Waseem Kaialy (2076586), Ticehurst, Martyn, Larhrib, Hassan, Kaialy, Waseem, Ticehurst, Martyn D, Martyn Ticehurst (2076583), Nokhodchi, Ali, Larhrib, El Hassan, Ali Nokhodchi (4465915)   +9 more
core   +1 more source

Factors influencing the surface quality of polished tool steels

, 2014
Today’s demands on surface quality of moulds for injection moulding of plastic components involve no/low defect contents and roughness levels in the nm-range for high gloss applications.
Rebeggiani, Sabina,, Rosén, Bengt-Göran,   +1 more
core   +2 more sources