Results 141 to 150 of about 4,007,124 (352)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Surface Quality Management and Condition Monitoring to Ensure Reliable Quality Decisions

, 2023
G. Gutmann, M. Hoenen
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Enhancing Fatigue Life of Metal Parts Produced by High-Speed Laser Powder Bed Fusion Through In Situ Surface Quality Improvement

Journal of Manufacturing and Materials Processing
The poor surface quality of the metal parts produced by laser powder bed fusion limits their application in load-bearing components, as it promotes crack initiation under cyclic loadings.
Daniel Ordnung, Mirko Sinico, Thibault Mertens, Han Haitjema, Brecht Van Hooreweder   +4 more
doaj   +1 more source

Spatio-temporal variations in surface water quality parameters of Kameng drainage, Eastern Himalaya, Arunachal Pradesh, India [PDF]

, 2021
Kishor Kunal, Parvaiz Ahmad Ganie, Deepjyoti Baruah, Garima, A.K. Jaiswar, SP Shukla, Dandadhar Sarma, P Khandu Thungon   +7 more
openalex  

Anthropogenic Effects on Surface Water Quality Assessment in Baitarani River Basin, Odisha Using GIS and MCDM Techniques

, 2023
Abhijeet Das
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Turn+: A MATLAB-based software for dynamic turning, chatter analysis, and surface roughness prediction

SoftwareX
Turning and boring processes are widely used to machine shafts, tubes, casings, and rings across sectors from automotive to aerospace, yet productivity is often limited by regenerative chatter, which couples cutting mechanics with tool–workpiece dynamics,
Gorka Urbikain-Pelayo, Daniel Olvera-Trejo, Luis Norberto López de Lacalle, Alex Elías-Zúñiga   +3 more
doaj   +1 more source

Possibilities of Small Water Reservoir Impact Improvement on Surface Water Quality in Agricultural Landscape [PDF]

, 2018
Michal Kriška Dunajský, Miroslava Pumprlová Němcová, Jana Konečná, Petr Karásek, Jana Podhrázská   +4 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source