Results 131 to 140 of about 1,431,352 (314)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Robust estimation of tear film surface quality in lateral shearing interferometry
, 2009 Interferometry is a sensitive technique for recording tear\ud film surface irregularities in a noninvasive manner. At the same time, the technique is hindered by natural eye movements resulting in measurement noise.
Iskander, Robert, Szczesna, Dorota
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Continuous meteorological surface measurement during METEOR cruise M11/5
, 2006 Continuous meteorological surface measurement during METEOR cruise M11/
WOCE Surface Meteorology Data, WOCEMET +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Influences of surface quality on the rolling contact fatique behaviour of ceramics
A novel eccentric lapping machine was designed by the author and manufactured in-house, to serve as a test bench to investigate the finishing process parameters in relation to surface quality, as well as the feasibility of accelerating the finishing ...
Kang, J.
core
Variability and uncertainty in measuring sea surface temperature
, 2012 Sea Surface Temperature (SST) measurement is one of the most easily obtainable climate variables. However, it is challenging to meet the required absolute accuracy and long term stability whether the data are derived by in situ or satellite measurements.
Wimmer, Werenfrid
core
Continuous meteorological surface measurement during HAKUHO MARU cruise 49HH932_1
, 2006 Continuous meteorological surface measurement during HAKUHO MARU cruise ...
WOCE Surface Meteorology Data, WOCEMET +3 more
core +1 more source
Fiber Laser Cutting of AISI 431 Martensitic Stainless Steel: An Experimental Investigation
Engineering ProceedingsThis work explores the fiber laser cutting of AISI 431 martensitic steel using an optimized technique of RSM-BBD. A significant increase in gas pressure, power, and cutting speed improved material removal by 62.4%.
Balasubramaniyan Chandrasekaran +5 more
doaj +1 more source