Results 141 to 150 of about 12,066,747 (304)

Quality Improvement Division Annual Report 2016

open access: yes, 2017
This report provides a high level overview of work completed by the Quality Improvement Division (QID) in 2016. In 2016 QID focused on developing and articulating the Framework for Improving quality that linked together the areas of work in Quality ...
Quality Improvement Division
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Quality Improvement Division Operational Plan 2017

open access: yes, 2017
The Quality Improvement Division provides advice and support quality improvement projects and initiatives. We do this by partnering with frontline services however the implementation of these programmes remains with the leadership of frontline ...
Quality Improvement Division
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

National Quality Improvement Team Annual Report 2017

open access: yes, 2018
This report is a high level overview of work completed by the National Quality Improvement Team (formerly known as the Quality Improvement Division) in 2018.
National Quality Improvement Team
core  

Representations of facial features and surface quality in monkey area TE compared to neural network models. [PDF]

open access: yesFront Neural Circuits
Shioya K   +15 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Quality and Patient Safety Division Annual Report 2014

open access: yes, 2015
A work plan is developed on an annual basis to support the quality and patient safety objectives in the National Service Plan. This report reviews the work completed in 2014 in delivery of the 2013 plan.
Quality Improvement Division
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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