Results 41 to 50 of about 15,178 (240)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

SURFACE SUBSIDENCE MONITORING AND ANALYZING IN BEIJING BASED ON INTERFEROMETRIC POINT TARGET ANALYSIS [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Temporal and geometrical decorrelation often prevents SAR interferometry from being an operational tool for surface deformation monitoring. Moreover, atmospheric disturbances can strongly compromise the accuracy of the results.
Y. Sun, Y. Sun, L. Lu
doaj   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Prediction of Delayed Surface Subsidence Based on the Improved Knothe-n Model

Applied Sciences
The delayed surface subsidence caused by coal seam mining is a problem that cannot be ignored, while accurate prediction of the surface subsidence provides a guarantee of the safety and stability of the relevant areas.
Jianhui Dong, Chengqian Tang, Xiao Liu, Yangdan Dong   +3 more
doaj   +1 more source

Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to evaluate the correlation and agreement between ultrasonography and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA.
Anne C. Bull Haaversen, Lene K. Brekke, Tanaz A. Kermani, Øyvind Molberg, Andreas P. Diamantopoulos   +4 more
wiley   +1 more source

Estimation of surface subsidence during tunneling

IOP Conference Series: Earth and Environmental Science, 2019
Abstract The limitations of the traditional methods of assessing the surface subsidence and the state of structures and natural objects in mining operations are shown. An innovative approach to predicting the surface subsidence during tunneling is proposed.
L P Vershinina, M I Vershinin
openaire   +1 more source

Research on Strip Filling Surface Subsidence Rule [PDF]

Proceedings of the Taishan Academic Forum - Project on Mine Disaster Prevention and Control, 2014
For recycling the remaining coal pillars resources in strip mining, a repeated mining method of using the strip filling replacement of strip coal pillar is proposed, a technical principle of strip filling controlling surface subsidence is illustrated, and the main filling factors which influence the surface subsidence rule are analyzed, FLAC3D is used ...
Jian Hao, Jingyu Zhang, Minhua Qi, Yongkui Shi   +3 more
openaire   +1 more source

Cognitive Behavioral Therapy for Youth with Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, Accepted Article.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

A Novel Surface Subsidence Prediction Model Based on Stochastic Medium Theory for Inclined Coal Seam Mining

Advances in Civil Engineering, 2023
Most coal resources are deposited in the form of inclined coal seams, and surface subsidence basin morphology induced by the mining of inclined coal seams is frequently skewed. The probability integral method with symmetrical distribution characteristics
Weitao Yan, Junting Guo, Shaoge Yan, Yueguan Yan, Wei Tang   +4 more
doaj   +1 more source