Results 101 to 110 of about 9,804,723 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Temperature of Moon's Surface [PDF]

Nature, 1877
IN a recent number of Les Mondes (tome xliv., No. I, September 6, 1877), M. l'Abbe F. Raillard puts forward a theory to explain the reddish tinge acquired by the moon during a total eclipse, attributing it possibly to the great elevation of temperature caused by the continuous exposure of its surface for many days previous to the solar rays, which he ...
openaire   +2 more sources

The Surface Temperature of the Moon [PDF]

Australian Journal of Physics, 1953
Results of numerical calculations are given for (i) the fall in surface temperature during a lunar eclipse, (ii) the variation in surface temperature at the equator during a lunation, and (iii) the variation in microwave temperature at the equator during a lunation.
openaire   +1 more source

Global analysis of night marine air temperature and its uncertainty since 1880: the HadNMAT2 Dataset [PDF]

, 2013
An updated version of the Met Office Hadley Centre’s monthly night marine air temperature dataset is presented. It is available on a 5? latitude-longitude grid from 1880 as anomalies relative to 1961-1990 calendar-monthly climatological average night ...
Berry, D.I., Moat, B.I., Nick A. Rayner, Bengamin I. Moat, John J. Kennedy, Michael Saunby, Elizabeth C. Kent, Parker, D.E., Kennedy, J.J., Rayner, N.A., David E. Parker, Kent, E.C., David I. Berry, Saunby, M.   +13 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Uncertainty estimates in regional and global observed temperature changes: A new data set from 1850 [PDF]

, 2006
The historical surface temperature data set HadCRUT provides a record of surface temperature trends and variability since 1850. A new version of this data set, HadCRUT3, has been produced, benefiting from recent improvements to the sea surface ...
P. Brohan, Jones, P. D., Harris, I., Tett, Simon F. B., P. D. Jones, Kennedy, John J., Kennedy, J. J., Harris, Ian, Brohan, P., Tett, S. F. B., I. Harris, Brohan, Philip, Jones, Philip D., S. F. B. Tett, J. J. Kennedy   +14 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effect of nutritional pen construction on the thermal performance of broilers

Journal of Applied Poultry Research
SUMMARY: Nutritional test pens are commonly used to segregate and geolocate birds in commercial-scale broiler houses to control spatial variation from the environment.
K.G. Griggs, J.D. Davis, J.L. Purswell, G.D. Chesser, C.M. Edge, J.C. Campbell   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Evaluation of the lake model FLake over a coastal lagoon during the THAUMEX field campaign

Tellus: Series A, Dynamic Meteorology and Oceanography, 2013
The THAUMEX measurement campaign, carried out during the summer of 2011 in Thau, a coastal lagoon in southern France, focused on episodes of marine breezes. During the campaign, three intensive observation periods (IOPs) were conducted and a large amount
Patrick Le Moigne, Dominique Legain, Franck Lagarde, Miguel Potes, Diane Tzanos, Eric Moulin, Joel Barrié, Rui Salgado, GRéGORY Messiaen, Annie Fiandrino, Sylvie Donier, Olivier Traullé, Maria João Costa   +12 more
doaj   +1 more source