Results 111 to 120 of about 9,804,723 (309)

Page 1 SOME REMARKS ON MECHANISMS FOR THE REGULATION OF TROPICAL

, 2008
It hardly needs elaboration that the regulation of tropical sea surface temperature is a central problem in climate, with repercussions ranging from the paleoclimatic domain (e.g. climate of the last glacial maximum vs.
R. T. Pierrehumbert, Sea Surface Temperature   +1 more
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Comparative Study of Surface Temperature Behavior of Commercial Li-Ion Pouch Cells of Different Chemistries and Capacities by Infrared Thermography

Energies, 2015
The non-uniform surface temperature distribution of a battery cell results from complex reactions inside the cell and makes efficient thermal management a challenging task. This experimental work attempts to determine the evolution of surface temperature
Shovon Goutam, Jean-Marc Timmermans, Noshin Omar, Peter Van den Bossche, Joeri Van Mierlo   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Note on ignition by a hot catalytic surface [PDF]

, 1981
In a previous paper [1], we applied asymptotic methods based on large values of the nondimensional activation temperature to study ignition of a reactive material, semi-infinite in extent, subjected to a step increase in temperature at its planar surface.
Williams, F.A., Liñán Martínez, Amable   +1 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Sensitivity of Surface Temperature to Land Use and Land Cover Change‐Induced Biophysical Changes: The Scale Issue

Geophysical Research Letters, 2019
While the signs of the sensitivities of surface temperature (Ts) to land use and land cover change‐induced biophysical changes are relatively well understood, their exact magnitude and how their magnitude depends on the scale characterizing the size of ...
Dan Li, Liang Wang
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Downscaling the Impacts of Large-Scale LUCC on Surface Temperature along with IPCC RCPs: A Global Perspective

Energies, 2014
This study focuses on the potential impacts of large-scale land use and land cover changes (LUCC) on surface temperature from a global perspective.
Xiangzheng Deng, Chunhong Zhao, Yingzhi Lin, Tao Zhang, Yi Qu, Fan Zhang, Zhan Wang, Feng Wu   +7 more
doaj   +1 more source