Results 51 to 60 of about 5,030,159 (295)

Chromium Cycling in Redox‐Stratified Basins Challenges δ53Cr Paleoredox Proxy Applications

Geophysical Research Letters, 2022
Chromium stable isotope composition (δ53Cr) is a promising tracer for redox conditions throughout Earth's history; however, the geochemical controls of δ53Cr have not been assessed in modern redox‐stratified basins.
David J. Janssen, Jörg Rickli, Martin Wille, Oscar Sepúlveda Steiner, Hendrik Vogel, Olaf Dellwig, Jasmine S. Berg, Damien Bouffard, Mark A. Lever, Christel S. Hassler, Samuel L. Jaccard   +10 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Machine learning reveals that sodium concentration and temperature influence alkenone occurrence in Swiss and worldwide freshwater lakes

Frontiers in Earth Science
Lacustrine alkenones are increasingly reported in freshwater lakes worldwide, which makes them a very promising proxy to reconstruct past continental temperatures.
Céline Martin, Nora Richter, Ronald Lloren, Linda Amaral-Zettler, Linda Amaral-Zettler, Nathalie Dubois   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Temperature modulates stress response in mainstream anammox reactors

Communications Biology, 2021
Niederdorfer et al. show that different anaerobic ammonium oxidizing (anammox) bacterial species and other key biofilm taxa vary in their transcriptional responses as a function of temperature and dissolved oxygen disturbances in an engineered ecosystem.
Robert Niederdorfer, Damian Hausherr, Alejandro Palomo, Jing Wei, Paul Magyar, Barth F. Smets, Adriano Joss, Helmut Bürgmann   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Human–climate–environment interactions in Espiritu Santo, Vanuatu during the past millennium

Frontiers in Earth Science
Over the past millennium, the tropical Pacific Islands of Remote Oceania have experienced significant transformations caused by different waves of human settlement and climatic variability.
Giorgia Camperio, Giorgia Camperio, S. Nemiah Ladd, Matiu Prebble, Matiu Prebble, Matiu Prebble, Cindy De Jonge, Tobias Schneider, Elena Argiriadis, Elena Argiriadis, Ronald Lloren, Ronald Lloren, Daniel B. Nelson, Amicie A. Delahaie, Amicie A. Delahaie, Christiane Krentscher, Nathalie Dubois, Nathalie Dubois   +17 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source