Results 41 to 50 of about 163,730 (266)

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Blast-Assisted Subsurface Characterisation Using a Novel Distributed Acoustic Sensing Setup Based on Geometric Phases

open access: yesSensors, 2023
A novel DAS setup based on geometric phases in coherent heterodyne detection is applied for the first time to the characterisation of the Earth’s subsurface.
Sabahat Shaheen   +2 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

open access: yesFEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno   +3 more
wiley   +1 more source

On the Possibility of Electromagnetic Surface Waves [PDF]

open access: yesProceedings of the National Academy of Sciences, 1954
The question of electromagnetic surface waves propagating along a plane of discontinuity between two different media was the subject of some diversity of opinion. It is related to the equally unsettled question about the merits of the conflicting solutions given by A. Sommerfeld (1) and H. Weyl (2) for the field of an electric dipole oscillating at the
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Polarization conversion with a photonic crystal slab [PDF]

open access: yesJournal of the European Optical Society-Rapid Publications, 2008
We show that a photonic crystal slab can enable efficient polarization conversion. Two mechanisms are identified. The first mechanism relies on the anisotropy of the bulk properties of the metamaterial and is mediated by interferences.
Laroche Marine   +3 more
doaj   +1 more source

Impact of a Turbulent Ocean Surface on Laser Beam Propagation

open access: yesSensors, 2022
The roughness of the ocean surface significantly impacts air-to-sea imaging, oceanographic monitoring, and optical communication. Most current and previous methods for addressing this roughness and its impact on optical propagation are either entirely ...
Omar Alharbi, Tim Kane, Diane Henderson
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

Relocation of Light and Moderate‐Magnitude (M4–6) Seismicity Along the Central Mid‐Atlantic

open access: yesGeochemistry, Geophysics, Geosystems, 2018
We estimate precise relative epicentroid locations of earthquakes along the Mid‐Atlantic Ridge (MAR) between 12°N and 19°N using intermediate‐period Rayleigh and Love wave cross‐correlation measurements.
K. Michael Cleveland   +2 more
doaj   +1 more source

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