Results 61 to 70 of about 6,465,054 (251)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Impact of Station Relocation on Observed Surface Wind Measurement Data and Its Application Effectiveness

应用气象学报
Surface wind speed time series from national meteorological stations are frequently utilized in studies of wind climate change analysis, wind energy resource assessment, and engineering considerations for wind resistance.
Zhang Yongshan, Zhao Xiaodong, Yuan Chunhong, Song Lili   +3 more
doaj   +1 more source

Diurnal Variations in Surface Wind over the Tibetan Plateau

Atmosphere, 2019
This study uses hourly surface wind direction and wind speed observations from 53 meteorological stations on the Tibetan Plateau (TP) (70–105° E, 25–45° N) between 1995 and 2017 to investigate diurnal variations in the surface wind ...
Yufei Zhao, Jianping Li, Qiang Zhang, Xiaowei Jiang, Aixia Feng   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Climatic Impacts of Large‐Scale Wind Farms in Arid and Semi‐Arid Region in China: A Case Study of the Huitengxile Wind Farm in Inner Mongolia

Wind Energy
With the rapid expansion of China's wind power industry, the local climatic impacts of large‐scale wind farms, particularly in arid and semi‐arid regions, have attracted increasing attention.
Xiashu Su, Entao Yu, Dongwei Liu
doaj   +1 more source

Surface profile prediction and analysis applied to turning process [PDF]

, 2008
An approach for the prediction of surface profile in turning process using Radial Basis Function (RBF) neural networks is presented. The input parameters of the RBF networks are cutting speed, depth of cut and feed rate.
LU, Chen, COSTES, Jean-Philippe
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Influence of Indian Ocean Dipole on Surface Wind Speed Variation in Coastal South China

Redai dili
Wind speed is an important parameter reflecting the climate and environmental conditions on the Earth's surface. It is also a pivotal factor influencing wind energy, a renewable and clean energy source.
Yan Shengjiang, Xie Yu, Zhou Houyun
doaj   +1 more source

Generic maximum power point tracking controller for small-scale wind turbines [PDF]

, 2012
The output power of a wind energy conversion system (WECS) is maximized if the wind rotor is driven at an optimal rotational speed for a particular wind speed. To achieve this, a Maximum Power Point Tracking (MPPT) controller is usually used.
Jovanovic, Milutin, Narayana, Mahinsasa, Putrus, Ghanim, Leung, Pak Sing, McDonald, Stephen   +4 more
core   +1 more source