Results 71 to 80 of about 6,465,054 (251)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Variability and trends of near-surface wind speed over the Tibetan Plateau: The role played by the westerly and Asian monsoon

Advances in Climate Change Research
Near-surface wind speed exerts profound impacts on many environmental issues, while the long-term (≥60 years) trend and multidecadal variability in the wind speed and its underlying causes in global high-elevation and mountainous areas (e.g., Tibetan ...
Gang-Feng Zhang, Cesar Azorin-Molina, Deliang Chen, Tim R. McVicar, Jose A. Guijarro, Kai-Qiang Deng, Lorenzo Minola, Jaeyeon Lee, Seok-Woo Son, Heng Ma, Pei-Jun Shi   +10 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The effect of ship shape and anemometer location on wind speed measurements obtained from ships

, 2005
Wind speed measurements obtained from ship-mounted anemometers are biased by the distortion of the airflow around the ship's hull and superstructure. These wind speed measurements are used both in numerical weather prediction and in climate studies and ...
Yelland, M.J., Moat, B.I., Molland, A.F.
core   +1 more source

Long-term wind resource and uncertainty estimation using wind records from Scotland as example [PDF]

, 2012
A systematic analysis of the sensitivity of a wind turbine’s output to changes in observed wind statistics between different sites in Scotland over available wind records of up to 43 years length was performed.
Fruh, Wolf-Gerrit; id_orcid
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A wind tunnel study of the mean airflow around a simple representation of a merchant ship [PDF]

, 2004
An investigation has been carried out to measure mean velocities above a solid block located in a wind tunnel. A Particle Image Velocimetry (PIV) system was used.
Yelland, M.J., Moat, B.I., Molland, A.F.
core   +1 more source

Identifying and Correcting for Residual Biases in the ASCAT and ERA5 Wind Speed Products

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The advanced scatterometer (ASCAT) instrument is a real-aperture radar that operates at C-band and measures backscatter from the ocean surface, from which near surface wind speed is estimated.
Gopal B. Sundaram, Christopher S. Ruf
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Wind turbine control using PI pitch angle controller [PDF]

, 2012
This paper suggests two methods to calculate the gains of a proportional-Integral pitch angle controller for a 5 MW wind turbine. The first method is analytical and the second one is based on simulation. Firstly, the power coefficient characteristics for
Hwas, Abdulhamed Moh Suliman, Katebi, Reza   +1 more
core   +3 more sources