Results 181 to 190 of about 11,710 (214)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

A bio-inspired adjustable posture quadruped robot with laterally undulating spine for terradynamically challenging environments. [PDF]

Sci Rep
Dutta SK, Ozkan-Aydin Y.
europepmc   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Explicit Preston's Equation Describes the Geometries of Egg-Shaped Tomato Cultivars and Its Potential for Estimating the Volume and Surface Area. [PDF]

Plants (Basel)
Huang W, Tan J.
europepmc   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Visuomotor Control Accuracy of Circular Tracking Movement According to Visual Information in Virtual Space. [PDF]

Sensors (Basel)
Lee J, Han K, Choi W, Kim J.
europepmc   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Sustainable paper manufacture from <i>Cladophora via</i> hydrochloric acid process.

RSC Sustain
Mihhels K, Kilpinen AT, Yousefi N, Abidnejad R, Paltakari J, Lizundia E, Blomster J, Kontturi E.   +7 more
europepmc   +1 more source

Simulation and Experimental Study on Abrasive-Tool Interaction in Drag Finishing Edge Preparation. [PDF]

Micromachines (Basel)
Yuan J, Yan Y, Fu Y, Zhou L, Wang X.
europepmc   +1 more source

Green revolution breeding favored water conservation, but weakened water use sensitivity to rising vapor pressure deficit in US spring wheat. [PDF]

Plant Physiol
Koehler T, Ding Q, Ossola E, Anderson J, Carminati A, Sadok W.   +5 more
europepmc   +1 more source